STK25 Antibody

中文名稱：

STK25兔多克隆抗體
貨號：

CSB-PA022842LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA022842LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022842LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) STK25 Polyclonal antibody
Uniprot No.：

O00506
基因名：

STK25
別名：

C86992 antibody; Serine/threonine kinase 25 antibody; Serine/threonine kinase 25 (STE20 homolog, yeast) antibody; Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a antibody; Serine/threonine kinase 25 (yeast) antibody; Serine/threonine protein kinase 25 antibody; Serine/threonine-protein kinase 25 antibody; SOK 1 antibody; SOK-1 antibody; SOK1 antibody; Ste20 like kinase antibody; Ste20 yeast homolog antibody; Ste20-like antibody; STE20-like kinase antibody; Ste20/oxidant stress response kinase 1 antibody; Sterile 20 (oxidant stress response kinase 1) antibody; Sterile 20/oxidant stress-response kinase 1 antibody; STK25 antibody; STK25_HUMAN antibody; Yeast Sps1/Ste20 related kinase 1 antibody; YSK 1 antibody; YSK1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein kinase 25 protein (1-426AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，STK25 Antibody (CSB-PA022842LA01HU)，的標記方式是Non-conjugated。對于STK25 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA022842LB01HU	STK25 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022842LC01HU	STK25 Antibody, FITC conjugated
Biotin	CSB-PA022842LD01HU	STK25 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
基因功能參考文獻：
1. STK25 regulates lipid partitioning in human liver cells by controlling TAG synthesis as well as lipolytic activity and thereby NEFA release from lipid droplets for beta-oxidation and TAG secretion. PMID: 26553096
2. Our results suggest that MST4, STK25 and PDCD10 are upregulated in prostate cancer and may play roles in prostate tumorigenesis. PMID: 25550858
3. This review notes that all 3 human germinal center kinase III genes consist of 12 exons and are ubiquitously expressed. In SOK1 and MST4, exon 1 encodes a 5' untranslated region, but this is not the case for MST3. PMID: 23889253
4. Down-modulation of STK25, but not STK24, rescued medulloblastoma cells from NGF-induced TrkA-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA and CCM2. PMID: 22782892
5. PDCD10 might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression. PMID: 22652780
6. Significantly higher STK25 levels were observed in the skeletal muscle of type 2 diabetic patients, compared with individuals with normal glucose tolerance. PMID: 22391949
7. The results of the study results indicate that attenuation of SOK1 enhanced cell migration and lead to changes in the expression of migration-associated proteins such as FAK and GM130. PMID: 21396913
8. In cultured human endothelial cells, CCM3 and STK25 regulated barrier function in a manner similar to CCM2, and STKs negatively regulated Rho by directly activating moesin. PMID: 20592472
9. 14-3-3zeta is a specific substrate for YSK1 that localizes to the Golgi apparatus, and potentially links YSK1 signaling at the Golgi apparatus with protein transport. PMID: 15037601
10. Ste20 family member (MAP4K3) that is required for maximal S6K (S6 kinase)/4E-BP1 [eIF4E (eukaryotic initiation factor 4E) that is required for maximal S6K (S6 kinase). PMID: 17253963
11. SOK1 entry into the nucleus is important for the cell death response PMID: 18364353
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亞細胞定位：

Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
組織特異性：

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.
數(shù)據(jù)庫鏈接：

HGNC: 11404

OMIM: 602255

KEGG: hsa:10494

STRING: 9606.ENSP00000325748

UniGene: Hs.516807

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