STIM2 Antibody, HRP conjugated

說明書

中文名稱：

STIM2兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA022830LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) STIM2 Polyclonal antibody
Uniprot No.：

Q9P246
基因名：

STIM2
別名：

FLJ39527 antibody; KIAA1482 antibody; STIM 2 antibody; STIM2 antibody; STIM2_HUMAN antibody; Stromal interaction molecule 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Stromal interaction molecule 2 protein (471-656AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
基因功能參考文獻：
1. Expression of full-length STIM1 with STIM2 in a 5:1 ratio causes suppression of sustained agonist-induced Ca(2+) oscillations and protects cells from Ca(2+) overload. PMID: 29581306
2. Stim2 deletion reduced SOCE by more than 90% in NIH 3T3 cells and abolishes STIM1 translocation to plasma membrane-associated ER membrane junctions. PMID: 29783744
3. With STIM2 being essential for life, but apparently not for development, newly available data demonstrate a complex and still intriguing behaviour that this review summarizes, updating current knowledge of STIM2 function [review] PMID: 28087881
4. The STIM2 protein play important roles in TGF-beta-induced EMT and these effects are related to both store-operated calcium entry and non-store-operated calcium entry. PMID: 28479254
5. What is less clear is how the spatial and temporal spread of intracellular Ca(2+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2+) release-activated Ca(2+) (CRAC) channels. PMID: 26911279
6. While STIM1 is a full Orai1-agonist, leucine-replacement of this crucial residue in STIM2 endows it with partial agonist properties, which may be critical for limiting Orai1 activation stemming from its enhanced sensitivity to store-depletion PMID: 24492416
7. These results imply that the splice variant STIM2.1 is an additional player tuning Orai1 activation in vivo. PMID: 25896806
8. STIM2.1 cannot activate Orai1 due to splicing in residues within the channel-activating domain (CAD). STIM2.1 confers a calcium dependent dominant-negative function on both STIM1 and STIM2 (STIM2.2). Affinity of the STIM2.1 calmodulin binding site within the CAD domain is increased compared to STIM2.2. PMID: 25896806
9. STIM2 enhances receptor-stimulated Ca(2) signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions. PMID: 25587190
10. STIM2beta does not by itself strongly bind Orai1, it is recruited to Orai1 channels by forming heterodimers with other STIM isoforms. PMID: 26033257
11. Imin channels are regulated by STIM2, TRPC3-containing INS channels are induced by STIM1, and TRPC1-composed Imax channels are activated by both STIM1 and STIM2. PMID: 25533457
12. The higher amplitude of store-operated Ca2+ entry was associated to the over-expression for Stim2, Orai2-3, and TRPC1 while Stim2 levels remained constant and Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in primary myelofibrosis. PMID: 24603752
13. the reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells PMID: 25143380
14. STIM2 is highly expressed and controls store-operated Ca(2+) entry in human melanoma. The invasive and migratory potential of melanoma cells was reduced upon silencing of STIM2. PMID: 24472175
15. Binding of the lysine rich domains of STIM1 and STIM2 to phosphatidylinositol 4,5 biphosphate rich liposomes depends on their oligomerization. PMID: 24044355
16. STIM2 is involved in spatial learning and plays an important role in ischemic-induced neuronal cell death during brain hypoxia. The absence of STIM2 reduces life expectancy in mice by sudden death. PMID: 198439
17. STIM2 regulates store-operated Ca2+ entry as a sensor of mild reductions in ER calcium levels. PMID: 23359669
18. The role of STIM2 in store operated calcium entry and its relevance in cellular physiology. [review] PMID: 22477146
19. Studies indicate that in vertebrates, stromal interaction molecule proteins STIM1 and STIM2 are expressed ubiquitously PMID: 22914293
20. It was shown that polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca2+ signaling by altering the ratio of STIM1 to STIM2. Overexpression of ornithine decarboxylase resulted in increased STIM1 but decreased STIM2 expression. PMID: 22592407
21. Stromal interaction molecule 2 is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. PMID: 22125164
22. Stim1 and Stim2 were increased in brains of chronic epileptic rodents and strongly expressed in hippocampal specimens from medial temporal lobe epilepsy patients. PMID: 21906591
23. STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets. PMID: 21321120
24. a new model for STIM2-mediated regulation of ORAI1 in which two distinct proteins, STIM2 and preSTIM2, control store-dependent and store-independent modes of ORAI1 activation. PMID: 21383014
25. Data suggest that divergent Ca(2+)- and SAM-dependent stabilization of the EF-SAM fold contributes to the disparate regulation of store-operated Ca(2+) entry by STIM1 and STIM2. PMID: 21217057
26. involved in both store-operated calcium entry and cell proliferation PMID: 20172609
27. STIM2 is a necessary partner of STIM1 for excitation-contraction coupling. PMID: 20436167
28. STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx. PMID: 16005298
29. STIM2 is an inhibitor of store-operated channel (SOC) activation and plays a coordinated role with STIM1 in controlling SOC-mediated Ca(2+) entry signals. PMID: 16860747
30. STIM2 has two modes of activating CRAC channels: a store-operated mode activated through depletion of ER Ca2+ stores by inositol 1,4,5-trisphosphate and store-independent activation mediated by cell dialysis; both regulated by calmodulin. PMID: 17905723
31. Study places STIM2 at the center of a feedback module that keeps basal cytosolic and endoplasmic reticulum Ca2+ concentrations within tight limits. PMID: 18160041
32. Our biophysical studies reveal a structural stability difference in the EF-SAM region between STIM1 and STIM2, which may account for their different biological functions. PMID: 18166150
33. distinct oligomerization dynamics of STIM isoforms have evolved to adapt to differential roles in Ca(2+) homeostasis and signaling PMID: 19019825
34. Data demonstrate that cellular levels of STIM1 and STIM2, which are key players in capacitative Ca2+ entry, depend on presenilins. PMID: 19111578
35. results provide evidence for a role of STIM1 protein in the control of Ca2+ influx in neutrophils excluding a STIM2 involvement in this process PMID: 19433064
36. Results show that the 55-amino-acid STIM2 terminus substituted within STIM1 strikingly enhances both Orai1-mediated Ca(2+) entry and constitutive coupling to activate Orai1 channels. PMID: 19487696
37. Translation initiation from a non-AUG (UUG) start site. PMID: 11463338
顯示更多

收起更多
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
組織特異性：

Expressed in all tissues and tumor cell lines examined.
數(shù)據(jù)庫鏈接：

HGNC: 19205

OMIM: 610841

KEGG: hsa:57620

STRING: 9606.ENSP00000417569

UniGene: Hs.744950

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human
VDAC1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human, Mouse, Rat