STARD13 Antibody

說明書

中文名稱：

STARD13兔多克隆抗體
貨號：

CSB-PA805513
規格：

￥2024
圖片：
Western blot analysis of extracts from K562 cells, using STA13 antibody.

Immunofluorescence analysis of A549 cells, using STA13 antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) STARD13 Polyclonal antibody
Uniprot No.：

Q9Y3M8
基因名：

STARD13
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from N-terminal of Human STA13.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IF	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
基因功能參考文獻：
1. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
2. Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
3. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
4. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
5. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
6. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
7. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
8. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
9. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
10. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
11. Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
12. role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
13. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
14. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
15. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974
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亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
組織特異性：

Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
數據庫鏈接：

HGNC: 19164

OMIM: 609866

KEGG: hsa:90627

STRING: 9606.ENSP00000338785

UniGene: Hs.156551

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