SSX1 Antibody

說明書

中文名稱：

SSX1兔多克隆抗體
貨號：

CSB-PA005093
規格：

￥1090
圖片：
Western Blot analysis of 22RV-1 SW480 cells using SSX Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q16384
基因名：

SSX1
別名：

Cancer/testis antigen 5.1 antibody; Cancer/testis antigen family 5 member 1 antibody; CT5.1 antibody; MGC150425 antibody; MGC5162 antibody; Protein SSX1 antibody; sarcoma; synovial; X chromosome related 1 antibody; SSRC antibody; SSX1 antibody; SSX1_HUMAN antibody; Synovial sarcoma antibody; Synovial sarcoma; X breakpoint 1 antibody; X breakpoint 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human SSX.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Could act as a modulator of transcription.
基因功能參考文獻：
1. SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression PMID: 29502955
2. Synovial sarcoma (SS) is considered as high-grade tumors with a poor prognosis. Novel therapies targeted at fusion oncogene, SS18-SSX-derived peptide vaccine, epidermal growth factor receptor, and vascular endothelial growth factor are the future hope in SS. PMID: 29893303
3. Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
4. In patients with Colon cancer, the expression of SSX1 gene was associated with a poor prognosis. PMID: 28631709
5. Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 tumors. Re-analysis of human SS18-SSX1 and SS18-SSX2 tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 expression in SS18-SSX1 tumors. PMID: 26947017
6. Data show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary synovial sarcoma. PMID: 26905812
7. a rare variant of the SS18-SSX1 fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed PMID: 25959879
8. SS18-SSX-induced Wnt/beta-catenin signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression. PMID: 24166495
9. The mRNA levels of SSX1 and SSX4 are associated with multiple myeloma clinical stage PMID: 24710929
10. These results suggest that the characteristic speckle localization pattern of SS18-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18-SSX fusion protein. PMID: 24130893
11. Knockdown of SS18-SSX1 in synovial sarcoma inhibits viability and induces apoptosis. PMID: 23716114
12. Study shows that the SS18-SSX1 oncogenic fusion usurps SWI/SNF-like BAF complexes, resulting in activation of Sox2, which drives proliferation. PMID: 23540691
13. siRNA targeting of SS18-SSX1 has therapeutic potential for the treatment of synovial sarcoma. PMID: 20198325
14. epigenetic features may define the cellular microenvironment in which SYT-SSX displays its functional effects PMID: 19936258
15. existence of fusion with SYT in synovial sarcoma PMID: 12037676
16. A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 on Ch20)/SSX1 fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1. PMID: 12696068
17. RT-PCR detection of SSX1 in paraffin-embedded tissue allowed for molecular diagnosis of synovial sarcoma. PMID: 15735574
18. demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, chromosome 18 synovial sarcoma (SS18)/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects PMID: 16152617
19. SYT-SSX1 induces insulin-like growth factor II expression in fibroblast cells. PMID: 16247461
20. In conclusion, SS18-SSX and IGF-1R seem to play important but different roles in maintaining malignant growth of synovial sarcoma cells. PMID: 18267106
21. siRNA targeting of SS18-SSX1 may have therapeutic potential in the treatment of synovial sarcomas. PMID: 18714179
22. We evaluated the correlations among the expression levels of NY-ESO-1, LAGE-1 and SSX-1 and clinical parameters in hepatocellular carcinoma patients PMID: 19212631
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相關疾病：

A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
蛋白家族：

SSX family
組織特異性：

Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and
數據庫鏈接：

HGNC: 11335

OMIM: 312820

KEGG: hsa:6756

STRING: 9606.ENSP00000366118

UniGene: Hs.434142

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