SRRM4 Antibody

中文名稱：

SRRM4兔多克隆抗體
貨號：

CSB-PA012292LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat kidney tissue, Mouse lung tissue
All lanes: SRRM4 antibody at 4.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa

IHC image of CSB-PA012292LA01HU diluted at 1:500 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SRRM4 Polyclonal antibody
Uniprot No.：

A7MD48
基因名：

SRRM4
別名：

SRRM4 antibody; KIAA1853 antibody; Serine/arginine repetitive matrix protein 4 antibody; Medulloblastoma antigen MU-MB-2.76 antibody; Neural-specific serine/arginine repetitive splicing factor of 100 kDa antibody; Neural-specific SR-related protein of 100 kDa antibody; nSR100 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SRRM4 Antibody (CSB-PA012292LA01HU)，的標記方式是Non-conjugated。對于SRRM4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA012292LB01HU	SRRM4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012292LC01HU	SRRM4 Antibody, FITC conjugated
Biotin	CSB-PA012292LD01HU	SRRM4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions.
基因功能參考文獻：
1. data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. PMID: 29759485
2. SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition. PMID: 27180064
3. Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism. PMID: 27984743
4. The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. PMID: 26071481
5. Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. PMID: 25525873
6. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058
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亞細胞定位：

Nucleus.
蛋白家族：

NSR100 family
組織特異性：

Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.
數據庫鏈接：

HGNC: 29389

OMIM: 613103

KEGG: hsa:84530

STRING: 9606.ENSP00000267260

UniGene: Hs.744964

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