SPTBN1 Antibody, Biotin conjugated
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中文名稱：SPTBN1兔多克隆抗體, Biotin偶聯(lián)
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貨號(hào)：CSB-PA733819LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) SPTBN1 Polyclonal antibody
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Uniprot No.：
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基因名：SPTBN1
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別名：Beta G spectrin antibody; Beta II spectrin antibody; Beta spectrin 2 antibody; Beta spectrin II antibody; Beta-II spectrin antibody; betaSpII antibody; brain 1 antibody; ELF antibody; Embryonic liver beta fodrin antibody; Fodrin beta chain antibody; non-erythroid beta chain 1 antibody; Spectrin antibody; Spectrin beta chain antibody; Spectrin, beta, non erythrocytic 1 antibody; Spectrin, non erythroid beta chain 1 antibody; SPTB2 antibody; SPTB2_HUMAN antibody; SPTBN1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Spectrin beta chain, non-erythrocytic 1 protein (2096-2256AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
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基因功能參考文獻(xiàn)：
- c-Met overexpression, HER-2 gene amplification, and SPTBN1-ALK gene fusion can coexist in lung adenocarcinoma and may become a potential biomarker of cancer refractory to crizotinib, chemotherapy, and radiotherapy as well as of a relatively poor prognosis. PMID: 27496196
- Subjects whose head and neck tumors expressed spectrin were 4.60 times more likely (hazard ratio; 95% confidence interval: 1.88-11.25) to die at any given time when compared with those without spectrin (P = .001). PMID: 27095047
- TGF-beta1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection. PMID: 25880619
- betaII spectrin is critical for normal myocyte electric activity. Dysfunction in the betaII spectrin-dependent cytoskeleton in cardiomyocytes contributes to human arrhythmia. PMID: 25632041
- decreased SPTBN1 and kallistatin gene expression associated with decreased relapse-free survival in hepatocellular carcinoma PMID: 25307947
- in human HCC tissues, SPTBN1 expression correlated negatively with expression levels of STAT3, ATF3, and CREB2; SMAD3 expression correlated negatively with STAT3 expression PMID: 25096061
- genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in SPTBN1 (rs11898505) is associated with osteoporotic fractures and bone mineral density of lumbar spine in aging women. PMID: 22798246
- Results suggest that epigenetic silencing of SPTBN1 (beta2SP) is a new potential causal factor in BWS patients. PMID: 20739274
- reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene PMID: 20886430
- High affinity and slow overall kinetics of association/dissociation of beta II-spectrin may suit it well to a role in strengthening cell junctions and providing stable anchorage for transmembrane proteins at points specified by cell-adhesion molecules. PMID: 12820899
- Quantitative analysis of erythrocyte membrane proteins revealed increase in beta-spectrin from patients with homozygous and heterozygous forms of beta-thalassemia. PMID: 15310273
- ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells PMID: 17074766
- because both the T2159E mutant and the wild-type allow neuritogenesis, we conclude that the short C-terminal betaII-spectrin is phosphorylated during this process PMID: 17088250
- TGF-beta signaling and Smad adaptor embryonic liver fodrin (ELF) suppress human hepatocarcinogenesis, potentially through cyclin D1 deregulation. PMID: 17546056
- E-cadherin thus requires both ankyrin-G and beta-2-spectrin for its cellular localization in early embryos as well as cultured epithelial cells. PMID: 17620337
- Our results therefore indicate the importance of N-terminal region for lipid-binding activity of the beta-spectrin ankyrin-binding domain and its substantial role in maintaining the spectrin-based skeleton distribution. PMID: 17716929
- Characterization of the 2p21 breakpoint identified the SPTBN1 gene in myeloproliferative disorders. PMID: 18262053
- ELF, a TGF-beta adaptor and signaling molecule, functions as a critical adaptor protein in TGF-beta modulation of angiogenesis as well as cell cycle progression. PMID: 18704924
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亞細(xì)胞定位：Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族：Spectrin family
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組織特異性：Isoform 2 is present in brain, lung and kidney (at protein level).
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數(shù)據(jù)庫鏈接：
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