SPAM1 Antibody

中文名稱：

SPAM1兔多克隆抗體
貨號：

CSB-PA022471LA01HU
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

The polyclonal antibody CSB-PA022471LA01HU was produced in rabbits against SPAM1 using recombinant human Hyaluronidase PH-20 protein (36-490aa) as the immunogen. After the purification process using protein G affinity chromatography, the antibody achieved a purity level of up to 95%.

This SPAM1 polyclonal antibody is specific to human SPAM1 proteins and may be used to detect the endogenous levels of SPAM1 protein. Quality testing has been conducted specifically for ELISA, allowing users to quantitatively or qualitatively measure the SPAM1 protein with this antibody.
產品名稱：

Rabbit anti-Homo sapiens (Human) SPAM1 Polyclonal antibody
Uniprot No.：

P38567
基因名：

SPAM1
別名：

epididymis secretory sperm binding protein Li 96n antibody; HEL-S-96n antibody; HYA1 antibody; HYAL PH-20 antibody; HYAL PH20 antibody; Hyal-PH20 antibody; HYAL1 antibody; HYAL3 antibody; HYAL5 antibody; HYALP_HUMAN antibody; Hyaluronidase PH-20 antibody; Hyaluronoglucosaminidase PH-20 antibody; MGC26532 antibody; PH-20 Hyaluronidase antibody; PH20 antibody; PH20 Hyaluronidase antibody; SPAG15 antibody; SPAM-1 antibody; Spam1 antibody; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antibody; Sperm adhesion molecule 1 antibody; Sperm surface protein PH-20 antibody; Sperm surface protein PH20 antibody; zona pellucida binding antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Hyaluronidase PH-20 protein (36-490AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SPAM1 Antibody (CSB-PA022471LA01HU)，的標記方式是Non-conjugated。對于SPAM1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022471LB01HU	SPAM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022471LC01HU	SPAM1 Antibody, FITC conjugated
Biotin	CSB-PA022471LD01HU	SPAM1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
基因功能參考文獻：
1. Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice. PMID: 25209425
2. results indicate that neither rHuPH20 nor its directly generated HA catabolites have inflammatory properties in the air pouch model, and rHuPH20 can instead inhibit some aspects of inflammation, such as neutrophil infiltration into the air pouch. PMID: 24778442
3. HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1. PMID: 23247813
4. The interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction. PMID: 23209833
5. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination. PMID: 23463525
6. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas deferens. It has hyaluronidase activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor elements. Its role may be in sperm maturation. PMID: 12932297
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Glycosyl hydrolase 56 family
組織特異性：

Testis.
數據庫鏈接：

HGNC: 11217

OMIM: 600930

KEGG: hsa:6677

STRING: 9606.ENSP00000345849

UniGene: Hs.121494

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