SPAG6 Antibody, FITC conjugated
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中文名稱：SPAG6兔多克隆抗體, FITC偶聯
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貨號：CSB-PA022467LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SPAG6 Polyclonal antibody
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Uniprot No.：
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基因名：SPAG6
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別名：axoneme central apparatus protein antibody; DKFZp434I153 antibody; MGC26276 antibody; PF16 antibody; PF16 protein homolog antibody; Protein PF16 homolog antibody; Repro SA 1 antibody; Repro-SA-1 antibody; SPAG6 antibody; SPAG6_HUMAN antibody; Sperm associated antigen 6 antibody; Sperm flagellar protein antibody; Sperm-associated antigen 6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Sperm-associated antigen 6 protein (343-428AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
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基因功能參考文獻：
- These results demonstrate that SPAG6 silencing induces PTEN expression to regulate apoptosis though the PI3K/AKT pathway, indicating that SPAG6 may be a potential therapeutic target for myelodysplastic syndromes. PMID: 29749435
- SPAG6 and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells. PMID: 28093071
- Study demonstrates that SPAG6 may regulate apoptosis through the TRAIL signal pathway by inhibiting the expression of FADD and the interactions between FADD and the TRAIL death receptors. PMID: 28393201
- studies demonstrate a role for Spag6 in the pathogenesis of OM in mice, possibly through its role in the regulation of cilia/basal body polarity through the PCP-dependent mechanisms in the middle ear and Eustachian tubes. PMID: 25393619
- These findings demonstrate that SPAG6 might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase proteins and p53, suggesting that SPAG6 may be a potential therapeutic target. PMID: 25405588
- SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia. PMID: 20668334
- Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein. PMID: 12391165
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亞細胞定位：Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme.
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組織特異性：Highly expressed in testis.
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