SOX3 Antibody
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中文名稱：SOX3兔多克隆抗體
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貨號：CSB-PA022429LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: SOX3 antibody at 8.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa -
IHC image of CSB-PA022429LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SOX3 Polyclonal antibody
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Uniprot No.：
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基因名：SOX3
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別名：GHDX antibody; MRGH antibody; PHP antibody; PHPX antibody; sox3 antibody; SOX3_HUMAN antibody; SOXB antibody; SRY (sex determining region Y)-box 3 antibody; SRY Box 3 antibody; SRY-related HMG-box gene 3 antibody; Transcription factor Sox-3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Transcription factor SOX-3 protein (4-118AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，SOX3 Antibody (CSB-PA022429LA01HU)，的標記方式是Non-conjugated。對于SOX3 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
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基因功能參考文獻：
- Pathogenic missense mutation in SOX3 gene is associated with intellectual disability, microphthalmia, coloboma, hypopituitarism, facial dysmorphology and dental anomalies, including microcephaly, retrognathia and a solitary median maxillary central incisor amongst other features. PMID: 29175558
- our data indicate that SOX3 may serve as an oncogene in osteosarcoma PMID: 29484385
- deletion of the SOX3 gene may have a role in intellectual disability with hemophilia B PMID: 27477789
- Results show that SOX3 is upregulated in human osteosarcoma (OS) tissues and provide evidence that SOX3 promotes migration, invasiveness, and EMT in OS cells via transcriptional activation of Snail1 expression. PMID: 28335789
- we provide a first map of the epigenetic landscape of SOX3 in pluripotent cells and during the early phases of neural differentiation. We found SOX3 gene to be non methylated from undifferentiated NT2/D1 to cells committed towards neural lineage. PMID: 28886103
- These findings demonstrate the novel mechanism by which Sox3 contributes to endometrial cancer stem cell invasion and suggest that repression of Sox3 by microRNA-194 may have therapeutic potential to suppress endometrial carcinoma metastasis. The cancer stem cell marker, CD133, might be the surface marker of endometrial cancer stem cell. PMID: 28618953
- Data indicate that SRY-box 3 transcription factor SOX-3 targets Src kinase in epithelial ovarian cancer (EOC) cells. PMID: 27251670
- SOX3 overdosage permits normal sex development in 46,XX individuals with random X inactivation. PMID: 25791725
- Translocations interrupting this region may also affect the gonadal development, possibly depending on the chromatin context of the recipient chromosome. SOX3 duplications may substitute SRY in some XX subjects PMID: 25351776
- Screening for SOX3 should be advised not only for hypopituitary patients with an ectopic posterior pituitary, but also for those with a structurally normal pituitary PMID: 25140394
- Our study provides additional evidence that deletion in polyalanine tracts of SOX3 is associated with hypopituitarism PMID: 24346842
- SOX3 duplication is a genetic cause for XH but has incomplete penetrance. Moreover, increased SOX3 levels may be a risk factor for NTD and potentially other clinical characteristics. PMID: 24737742
- the results point at CREB as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent. PMID: 24257117
- Overexpression of Sox3 is associated with esophageal squamous cell carcinoma. PMID: 23238694
- Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS). PMID: 23199197
- TGIF (TG-interacting factor) is an additional TALE superfamily member involved in the regulation of human SOX3 gene expression PMID: 22293114
- these results strongly support the pathogenicity of the identified insertions near SOX3 and establish X-linked congenital hypertrichosis syndrome as a genomic disorder. PMID: 21636067
- identified genomic rearrangements within the SOX3 regulatory region in three patients with XX male sex reversal PMID: 21183788
- SRY is a hybrid of DGCR8 and SOX3, and is regulated by the transcription factor CP2. PMID: 19902333
- Data demonstrated that overexpressed PBX1 and MEIS1 increased endogenous SOX3 protein expression in both uninduced and RA-induced NT2/D1 cells. PMID: 19799567
- Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency PMID: 12428212
- ... mechanisms underlying X-linked hypopituitarism are...being unravelled, with involvement of SOX3 in a pedigree with X-linked mental retardation ...isol. growth hormone defic., and PHF6 in two siblings with Borjeson-F-Leahmann syndrome. p. 1208 PMID: 14714741
- Three nucleotide substitutions (609 T-->C, 732 A-->C, and 978 G-->A) were identified, none of which altered the amino acid sequence, suggesting that they are polymorphic variants. PMID: 15292361
- Interestingly, all X linked hypopituitarism duplications contain SOX3 PMID: 15342697
- SUMO-1 represses transcriptional activity of SOX3. PMID: 15788563
- We conclude that both over- and underdosage of SOX3 are associated with similar phenotypes, consisting of infundibular hypoplasia and hypopituitarism but not necessarily MR. PMID: 15800844
- liganded RXRalpha is a potent activator of endogenous SOX3 protein expression PMID: 17005281
- Deregulation of SOX3 target genes may contribute to dysfunction of the hypothalamic-pituitary axis in X-linked Hypopituitarism patients. PMID: 17127446
- Mutation by deletion of a polyalanine tract does not segregate with mental retardation. PMID: 17627381
- Our data indicate that multiple CCAAT control elements are involved in the regulation of the SOX3 promoter, suggesting that NF-Y functions as a key regulator of SOX3 gene expression. PMID: 17910945
- of the Xq27.1 breakpoint localized it to a 90 kb interval 3' of the SOX3 gene, supporting a novel role of SOX3 misexpression in the development of Peters anomaly of the eye PMID: 17994562
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相關疾病：Panhypopituitarism X-linked (PHPX); Mental retardation, X-linked, with isolated growth hormone deficiency (MRXGH); 46,XX sex reversal 3 (SRXX3)
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亞細胞定位：Nucleus.
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