SNX6 Antibody

中文名稱：

SNX6兔多克隆抗體
貨號：

CSB-PA890766LA01HU
規格：

￥440
圖片：
Western blot
All lanes: SNX6 antibody at 4μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47, 34 kDa
Observed band size: 47 kDa

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA890766LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SNX6 Polyclonal antibody
Uniprot No.：

Q9UNH7
基因名：

SNX6
別名：

SNX6 antibody; Sorting nexin-6 antibody; TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6 antibody; N-terminally processed] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sorting nexin-6 protein (1-290AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SNX6 Antibody (CSB-PA890766LA01HU)，的標記方式是Non-conjugated。對于SNX6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA890766LB01HU	SNX6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA890766LC01HU	SNX6 Antibody, FITC conjugated
Biotin	CSB-PA890766LD01HU	SNX6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation.
基因功能參考文獻：
1. study confirms the utility of proximity-labeling methods, such as BioID, to screen for interactors of cell-surface receptors and has uncovered a role of one of these interactors, SNX6, in the IGF1R signaling cascade. PMID: 29530981
2. These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope. PMID: 25535984
3. Study observed that SNX6 increases BRMS1-dependent transcriptional repression. Moreover, over-expression of SNX6 was capable of diminishing trans-activation in a dose-dependent manner. PMID: 20830743
4. SNX6 modulates the retrograde trafficking and basal levels of BACE1, thereby regulating BACE1-mediated APP processing and Abeta biogenesis PMID: 20354142
5. These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates. PMID: 19935774
6. SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer PMID: 17148574
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亞細胞定位：

Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus.
蛋白家族：

Sorting nexin family
數據庫鏈接：

HGNC: 14970

OMIM: 606098

KEGG: hsa:58533

STRING: 9606.ENSP00000355217

UniGene: Hs.276523

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