SNTA1 Antibody

說明書

中文名稱：

SNTA1兔多克隆抗體
貨號(hào)：

CSB-PA289378
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA289378(SNTA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 80 μg, Lane 1-2: Human colon cancer and normal stomach tissue, Primary antibody: CSB-PA289378(SNTA1 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q13424
基因名：

SNTA1
別名：

59 kDa dystrophin-associated protein A1 acidic component 1 antibody; Acidic alpha 1 syntrophin antibody; Alpha 1 syntrophin antibody; Alpha-1-syntrophin antibody; dJ1187J4.5 antibody; Dystrophin associated protein A1 59kDa acidic component antibody; LQT12 antibody; OTTHUMP00000030650 antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody; SNT1 antibody; Snta1 antibody; SNTA1_HUMAN antibody; Syntrophin 1 antibody; Syntrophin-1 antibody; TACIP1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human SNTA1
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate.
基因功能參考文獻(xiàn)：
1. not associated with sudden infant death syndrome PMID: 28520217
2. Low SNTA expression is associated with non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma. PMID: 28941732
3. A novel SNTA1 variant is likely causative for drug induced long-QT syndrome by augmenting the late sodium current. PMID: 27028743
4. In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. PMID: 25757662
5. our results present a possible mechanism of Rac1 activation involving SNTA1 and emphasise its role in ROS generation, cell migration, and acquisition of malignancy. PMID: 24434436
6. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. PMID: 24014171
7. alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS translocation and nNOS-dependent mitochondrial biogenesis. PMID: 24235139
8. Calcium homeostasis mishandling in Duchenne muscular dystrophy myotubes depends on store operated calcium entry under the influence alpha1-syntrophin regulation as well as TRPV2-dependant cation influx. PMID: 23426965
9. The combined mutations of A261V-SNTA1 plus R800L-SCN5A increase the INa current late/peak ratio and time constants of current decay. PMID: 23376825
10. In contrast to stomach, lung, colon and rectal cancers, SNTA1 protein was found to be downregulated in esophageal cancers and upregulated in breast cancer. PMID: 21091386
11. alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction PMID: 16533813
12. These results establish an SNTA1-based nNOS complex attached to SCN5A as a key regulator of sodium current and suggest that SNTA1 be considered a rare long QT syndrome-susceptibility gene. PMID: 18591664
13. SNTA1 is a new susceptibility gene for LQTS. A257G-SNTA1 can cause gain-of-function of Na(v)1.5 similar to the LQT3. PMID: 19684871
14. Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. PMID: 20009079
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相關(guān)疾病：

Long QT syndrome 12 (LQT12)
亞細(xì)胞定位：

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton.
蛋白家族：

Syntrophin family
組織特異性：

High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11167

OMIM: 601017

KEGG: hsa:6640

STRING: 9606.ENSP00000217381

UniGene: Hs.31121

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