SNCAIP Antibody, HRP conjugated

說明書

中文名稱：

SNCAIP兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA896546LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SNCAIP Polyclonal antibody
Uniprot No.：

Q9Y6H5
基因名：

SNCAIP
別名：

Alpha synuclein interacting protein antibody; Alpha-synuclein-interacting protein antibody; MGC39814 antibody; SNCAIP antibody; SNCAP_HUMAN antibody; Sph1 antibody; Synphilin-1 antibody; Synphilin1 antibody; Synuclein alpha interacting protein (synphilin) antibody; Synuclein alpha interacting protein antibody; SYPH 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Synphilin-1 protein (309-553AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
基因功能參考文獻：
1. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain. PMID: 26465922
2. Synphilin-1 binds ATP, but not CTP. PMID: 25545246
3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity. PMID: 24829096
4. Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity PMID: 22828940
5. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation. PMID: 20849899
6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease. PMID: 21344240
7. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation. PMID: 20816781
8. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. PMID: 21103907
9. Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition. PMID: 20604806
10. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD. PMID: 19730898
11. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease PMID: 19857556
12. alpha-synuclein-synphilin-1 interaction significantly promotes the formation of cytoplasmic alpha-synuclein inclusions, which may have implications for Lewy body formation in neural cells PMID: 19762560
13. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. PMID: 11958831
14. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
15. a causative role of the R621C mutation in the synphilin-1 gene in Parkinson's disease PMID: 12761037
16. Changes in synuclein expression presage neurodegeneration in a Drosophila model of Parkinson disease. PMID: 12915459
17. Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release PMID: 14506261
18. role of aggresomes in cell viability was addressed in the context of over-expressing alpha-synuclein and its interacting partner synphilin-1 PMID: 14627698
19. Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies. PMID: 14645218
20. role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease PMID: 15322916
21. Parkin is a dual-function ubiquitin ligase. K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with Parkinson disease. PMID: 15728840
22. We confirm that synphilin-1 and parkin are components of majority of Lewy Bodies in Parkinson's disease and that both proteins are susceptible to proteasomal degradation. PMID: 15894486
23. GSK3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH PMID: 16174773
24. Synphilin-1A may contribute to neuronal degeneration in alpha-synuclein mutations and provides insights into the role of inclusion bodies in neurodegenerative disorders. PMID: 16595633
25. These results suggest that NUB1 indeed targets synphilin-1 to the proteasome for its efficient degradation, which, because of the resultant reduction in synphilin-1, suppresses the formation of synphilin-1-positive inclusions. PMID: 16877356
26. a novel specific interaction of synphilin-1 with the regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like intracytoplasmic inclusions PMID: 17327361
27. These findings suggest that parkin and synphilin-1 isoform expression changes play a significant role in the pathogenesis of LB diseases. PMID: 17467279
28. review:Isoform Synphilin-1A inclusions recruit both alpha-synuclein and synphilin-1. Aggregation of synphilin-1 and synphilin-1A seems to be protective to cells PMID: 17982729
29. specific effects of C621 mutant synphilin-1 on gene expression that correlate with its role as a susceptibility factor in Parkinson's disease PMID: 18292964
30. All four alpha-synuclein isoforms were affected in dementia with LB (Lewy bodies), most parkin transcript variants in common LB disease, and all synphilin-1 isoforms in Parkinson disease. PMID: 18335262
31. We found no evidence for association between genetic variability in synphilin-1 and Parkinson's disease PMID: 18366718
32. translocation to aggresomes required a special aggresome-targeting signal within the sequence of synphilin 1, an ankyrin-like repeat domain. PMID: 18635553
33. Synphilin-1 might be involved in motor function, and its accumulation in the central nervous system can cause motor impairments. PMID: 18782602
34. synphilin-1A has a novel role as a regulator of SIAH activity, modulating alpha-synuclein, and formation of Lewy body-like inclusions PMID: 19224863
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相關(guān)疾病：

Parkinson disease (PARK)
亞細(xì)胞定位：

Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
組織特異性：

Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta.
數(shù)據(jù)庫鏈接：

HGNC: 11139

OMIM: 168600

KEGG: hsa:9627

STRING: 9606.ENSP00000261368

UniGene: Hs.426463

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