SMARCC2 Antibody

說(shuō)明書(shū)

中文名稱(chēng)：

SMARCC2兔多克隆抗體
貨號(hào)：

CSB-PA851527LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HL60 whole cell lysate
All lanes: SMARCC2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 133, 125, 127 kDa
Observed band size: 170 kDa

Immunofluorescence staining of A549 cells with CSB-PA851527LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) SMARCC2 Polyclonal antibody
Uniprot No.：

Q8TAQ2
基因名：

SMARCC2
別名：

SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2), SMARCC2, BAF170
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human SWI/SNF complex subunit SMARCC2 protein (300-650aa)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，SMARCC2 Antibody (CSB-PA851527LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SMARCC2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱(chēng)	應(yīng)用
HRP	CSB-PA851527LB01HU	SMARCC2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA851527LC01HU	SMARCC2 Antibody, FITC conjugated
Biotin	CSB-PA851527LD01HU	SMARCC2 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
基因功能參考文獻(xiàn)：
1. BAF170 is important for neurogenesis in embryonic olfactory epithelium. PMID: 27611684
2. Identification of frameshift mutations in the SMARCC2 gene in gastric and colorectal cancers with microsatellite instability. PMID: 23030715
3. study finds Baf53 and Baf170 are highly regulated in HIV-1-infected cells PMID: 21699904
亞細(xì)胞定位：

Nucleus.
蛋白家族：

SMARCC family
組織特異性：

Ubiquitously expressed.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11105

OMIM: 601734

KEGG: hsa:6601

STRING: 9606.ENSP00000267064

UniGene: Hs.236030

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