SLCO2A1 Antibody

中文名稱：

SLCO2A1兔多克隆抗體
貨號(hào)：

CSB-PA856440LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, U87 whole cell lysate, K562 whole cell lysate, Rat brain tissue, Mouse heart tissue, Mouse liver tissue
All lanes: SLCO2A1 antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71 kDa
Observed band size: 71 kDa

IHC image of CSB-PA856440LA01HU diluted at 1:500 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA856440LA01HU diluted at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA856440LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

The SLCO2A1 polyclonal antibody from CUSABIO is a high-quality antibody that has been validated for use in ELISA, WB, IHC, and IF. The immunogen is the recombinant human SLCO2A1 protein (416-518aa). This SLCO2A1 antibody is purified using protein G and has a purity of over 95%. It has been shown to detect SLCO2A1 in human, mouse, and rat samples.

The SLCO2A1 protein, also known as prostaglandin transporter (PGT), mainly transports prostaglandins across cell membranes, particularly in the kidney and the gastrointestinal tract. Mutations in the SLCO2A1 gene can lead to a rare disorder known as primary hypertrophic osteoarthropathy (PHO).
產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SLCO2A1 Polyclonal antibody
Uniprot No.：

Q92959
基因名：

SLCO2A1
別名：

SLCO2A1 antibody; OATP2A1 antibody; SLC21A2 antibody; Solute carrier organic anion transporter family member 2A1 antibody; Prostaglandin transporter antibody; PGT antibody; Solute carrier family 21 member 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Solute carrier organic anion transporter family member 2A1 protein (416-518AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，SLCO2A1 Antibody (CSB-PA856440LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SLCO2A1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA856440LB01HU	SLCO2A1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856440LC01HU	SLCO2A1 Antibody, FITC conjugated
Biotin	CSB-PA856440LD01HU	SLCO2A1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Transports PGD2, as well as PGE1, PGE2 and PGF2A. Mediates the clearance of prostaglandins from the circulation through uptake across cell membrane which allows cytoplasmic oxidation and prostaglandin signal termination. May mediate the release of newly synthesized prostaglandins from cells and the transepithelial transport of prostaglandins (Probable).
基因功能參考文獻(xiàn)：
1. The findings reported here support causality of this SLCO2A1 mutation for autosomal recessive ICNC in this consanguineous Pakistani kindred. PMID: 27681482
2. In Japanese patients with chronic nonspecific multiple ulcers of the small intestine, 2 of the 4 patients had mutation in the SLCO2A1 gene, became resistant to medical therapy, and underwent strictureplasty or ileal resection after long-term follow-up. PMID: 27467110
3. in individuals carrying the SLCO2A1 A396T variant, the combination of thiazide-specific effects on free water generation and the increase in collecting duct water permeability from reduced SLCO2A1 activity combine to produce thiazide-induced hyponatremia PMID: 28783044
4. A novel missense mutation c.101T > C in the SLCO2A1 gene causes pachydermoperiostosis of the complete type. PMID: 28602931
5. Mutation analysis revealed a novel heterozygous mutation in the solute carrier organic anion transporter family member 2A1 gene at nucleotide 302 causing a substitution of the amino acid isoleucine to serine at codon 101 (p.IIe101Ser) in affected individuals. PMID: 27134495
6. We herein report patients with pachydermoperiostosis (PDP)due to SLCO2A1 mutation in a Korean family. Similar to other East Asian populations, the SLCO2A1 gene may be a possible mutation spot of PDP in the Korean population. PMID: 25810087
7. Data show that prostaglandin E3 (PGE3) uptake by prostaglandin transporter OATP2A1-expressing HEK293 cells (HEK/2A1) was the highest and followed by SLCO2B1 (HEK/1B1). PMID: 26692285
8. In this article we describe a novel mutation in the SLCO2A1 causing Pachydermoperiostosis in a Lebanese family PMID: 25059581
9. overexpression of SLCO2A1 could induce and knockdown inhibit the invasion of lung cancer cells. expression levels of p-mTOR, p-AKT and p-S6 were up-regulated or down-regulated with the overexpression or knockdown of SLCO2A1. PMID: 26464663
10. cytoplasmic OATP2A1 likely facilitates prostaglandin E2 loading into suitable intracellular compartment(s) for efficient exocytotic prostaglandin E2 release from colorectal cancer cells exposed to oxidative stress PMID: 26850138
11. findings indicate that loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy CNSU PMID: 26539716
12. SLCO2A1 and NOS3 are involved with prostaglandin reuptake/metabolism and nitric oxide production, respectively, and are consistently decreased in "non-Caucasian" fetal ductus arteriosus PMID: 26265282
13. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. PMID: 25433169
14. OATP2A1 also diminished the PGE2-mediated expression of interleukin-8 mRNA (IL-8) and hypoxia-inducible-factor 1alpha (HIF1alpha) protein in AGS-OATP2A1 cells. PMID: 25433165
15. SLCO2A1 has a role in familial digital clubbing, colon neoplasia, and NSAID resistance PMID: 24838973
16. a novel nonsense mutation p.E141* of the SLCO2A1 gene is associated with pachydermoperiostosis PMID: 24929850
17. Three novel mutations within the SLCO2A1 gene have been demonstrated to be associated with Chinese primary hypertrophic osteoarthropathy patients. PMID: 24153155
18. Identified two novel mutations in SLCO2A1. PMID: 24185079
19. genetic association study in population in China: Nine different SLCO2A1 mutations were identified in subjects with primary hypertrophic osteoarthropathy (PHO) in 7 previously undescribed families; different homozygous mutations of SLCO2A1 cause PHO. PMID: 23509104
20. Report SLCO2A1 is a novel gene responsible for pachydermoperiostosis in Japanese patients. PMID: 22906430
21. Mutations in the prostaglandin transporter SLCO2A1 cause primary hypertrophic osteoarthropathy with digital clubbing. PMID: 22696055
22. Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. PMID: 22553128
23. Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. PMID: 22331663
24. The findings confirmed that SLCO2A1 mutations inactivate prostaglandin E2 transport, and they indicated that mutations in SLCO2A1 are the pathogenic cause of primary hypertrophic osteoarthropathy. PMID: 22197487
25. expression in fetal membranesfound primarily in the choriodecidua PMID: 20357271
26. that PGT may play a role in transporting PGH(2) across cellular membranes. PMID: 20346915
27. Human endometrial stromal cells treated with a combination of cAMP and medroxyprogesterone acetate to induce decidualization showed an increase in protein and mRNA levels. PMID: 16339169
28. PGT level was significantly less in AD than in age-matched control brain homogenates. PMID: 18353443
29. The existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport. PMID: 19138942
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相關(guān)疾病：

Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2)
亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Organo anion transporter (TC 2.A.60) family
組織特異性：

Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.
數(shù)據(jù)庫鏈接：

HGNC: 10955

OMIM: 601460

KEGG: hsa:6578

STRING: 9606.ENSP00000311291

UniGene: Hs.518270

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