SLC52A2 Antibody

文獻引用 (2) 說明書

中文名稱：

SLC52A2兔多克隆抗體
貨號：

CSB-PA060150
規格：

￥1090
圖片：
Western Blot analysis of A549 cells using GPR172A Polyclonal Antibody
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HAB3
基因名：

SLC52A2
別名：

SLC52A2 antibody; GPR172A antibody; PAR1 antibody; RFT3 antibody; Solute carrier family 52 antibody; riboflavin transporter antibody; member 2 antibody; Porcine endogenous retrovirus A receptor 1 antibody; PERV-A receptor 1 antibody; Protein GPR172A antibody; Riboflavin transporter 3 antibody; hRFT3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human GPR172A.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Caspase-dependent apoptosis in Ribloflavin transporter deficiency iPSCs and derived motor neurons RJ Bostani,Cell death discovery,2024
Caspase-dependent apoptosis in Riboflavin Transporter Deficiency iPSCs and derived motor neurons S Moreno,researchsquare,2023

產品評價

靶點詳情

功能：

Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4-hydroxybutyrate (Probable).; (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
基因功能參考文獻：
1. RFVT2 gene and protein expression levels were higher in DLD-1 and HT-29 compared to Caco2 cells. In tumor tissues of patients with CRC, RFVT2 gene expression levels were increased, while protein expression was reduced, with a small reduction in riboflavin amount. PMID: 29715086
2. This is the second report of the genotype-phenotype correlation between this syndrome named spinocerebellar ataxia with blindness and deafness type 2 (SCABD2) and SLC52A2 gene. PMID: 29287867
3. Eight mutations in SLC52a2 were associated with Brown-Vialetto-Van Laere syndrome. PMID: 29053833
4. A novel SLC52A2 mutation identified in a family with spinocerebellar ataxia with blindness and deafness. PMID: 26669662
5. This study showed that Auditory neuropathy in Brown-Vialetto-Van Laere syndrome due to riboflavin transporter RFVT2 deficiency and improved by riboflavin treatment. PMID: 26918385
6. These results strongly implicate a potential role for SLC52A2 in riboflavin uptake by milk-producing MECs, a critical step in the transfer of riboflavin into breast milk. PMID: 26791833
7. Mutations in SLC52A2 result in a recognizable phenotype distinct from Brown-Vialetto-Van-Laere syndrome. PMID: 24616084
8. We demonstrate that SLC52A2 mutations cause reduced riboflavin uptake and reduced riboflavin transporter protein expression PMID: 24253200
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相關疾病：

Brown-Vialetto-Van Laere syndrome 2 (BVVLS2)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Riboflavin transporter family
組織特異性：

Highly expressed in brain, fetal brain and salivary gland. Weakly expressed in other tissues.
數據庫鏈接：

HGNC: 30224

OMIM: 607882

KEGG: hsa:79581

STRING: 9606.ENSP00000333638

UniGene: Hs.6459

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