SLC34A3 Antibody, HRP conjugated
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中文名稱：SLC34A3兔多克隆抗體, HRP偶聯
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貨號：CSB-PA854015LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLC34A3 Polyclonal antibody
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Uniprot No.：
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基因名：SLC34A3
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別名：HHRH antibody; Na(+) dependent phosphate cotransporter 2C antibody; Na(+) Pi cotransporter 2C antibody; Na(+)-dependent phosphate cotransporter 2C antibody; Na(+)/Pi cotransporter 2C antibody; NaPi 2c antibody; NaPi-2c antibody; NPT2C antibody; NPT2C_HUMAN antibody; NPTIIC antibody; SLC34A3 antibody; Sodium dependent phosphate transport protein 2C antibody; Sodium inorganic phosphate cotransporter IIC antibody; Sodium phosphate cotransporter 2C antibody; Sodium phosphate transport protein 2C antibody; Sodium-dependent phosphate transport protein 2C antibody; Sodium-phosphate transport protein 2C antibody; Sodium/inorganic phosphate cotransporter IIC antibody; Sodium/inorganic phosphate cotransporter; type IIC antibody; Sodium/phosphate cotransporter 2C antibody; solute carrier family 34 (sodium phosphate) member 3 antibody; solute carrier family 34 (sodium/phosphate contransporter); member 3 antibody; solute carrier family 34 (type II sodium/phosphate contransporter); member 3 antibody; Solute carrier family 34 member 3 antibody; type IIc Na+ Pi cotransporter antibody; Type IIc Na+/Pi cotransporter antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Sodium-dependent phosphate transport protein 2C protein (1-76AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.
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基因功能參考文獻：
- genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3 PMID: 29505567
- This is the report of a patient with compound heterozygous mutations of SLC34A3 and normal skeletal features. Biallelic mutations in SLC34A3 can thus be associated with hypercalciuria not accompanied by rickets. PMID: 24924704
- Individuals with mutations affecting both SLC34A3 alleles had a significantly increased risk of kidney stone formation or medullary nephrocalcinosis, namely 46% compared with 6% observed in healthy family members carrying only the wild-type allele. PMID: 24700880
- this study reports the first cases of hereditary hypophosphatemic rickets with hypercalciuria in Africa and describes a novel causal mutation within the SLC34A3 gene PMID: 23246670
- A man with hereditary hypophosphataemic rickets with hypercalciuria & his 3 heterozygous children had a mutation in intron 5 of gene SLC34A3 (NM_080877.2:c[ 448 +5G>A] + [ 448 +5G>A]). PMID: 22806288
- Data show 101-bp deletion in intron 9 of the SLC34A3 gene. PMID: 22672866
- SLC34A3 mutations (exons and introns) were searched in two previously not reported hereditary hypophosphatemic rickets with hypercalciuria kindreds, which resulted in the identification of three novel mutations. PMID: 22387237
- these data suggest that mutations in SLC34A3 in hereditary hypophosphatemic rickets with hypercalciuria result in defective processing and stability PMID: 22159077
- Functionally important sites in the predicted first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter (NaPi-IIa) were identified by cysteine scanning mutagenesis (Ehnes et al., 2004). PMID: 15504899
- NaP(i)-IIc has a key role in the regulation of phosphate homeostasis. PMID: 16358214
- Loss of function of the SLC34A3 protein presumably results in a primary renal tubular defect and is compatible with the hereditary hypophosphatemic rickets with hypercalciuria phenotype. PMID: 16358215
- Therefore, understanding the mechanisms that control the apical expression of NaPi-IIa and NaPi-IIc as well as their functional properties is critical to understanding how an organism achieves P i homeostasis. PMID: 16955105
- Hereditary hypophosphatemic rickets with hypercalciuria were speculated to be associated with the abnormal functions of phosphate transporter gene type IIc. PMID: 17968493
- A novel missense mutation in SLC34A3 causes hereditary hypophosphatemic rickets with hypercalciuria in humans. PMID: 18480181
- Novel mutation in the SLC34A3 gene in a patient with an unusual presentation of hereditary hypophosphatemic rickets with hypercalciuria. PMID: 19820004
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相關疾病：Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
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亞細胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：SLC34A transporter family
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數據庫鏈接：
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