SLC29A1 Antibody
-
中文名稱：SLC29A1兔多克隆抗體
-
貨號：CSB-PA021542GA01HU
-
規(guī)格：￥3,900
-
其他：
產(chǎn)品詳情
-
Uniprot No.：
-
基因名：SLC29A1
-
別名：Equilibrative NBMPR-sensitive nucleoside transporter antibody; equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter antibody; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter antibody; Equilibrative nucleoside transporter 1 antibody; es-type antibody; MGC1465 antibody; MGC3778 antibody; Nucleoside transporter antibody; Nucleoside transporter, es-type antibody; OTTHUMP00000016506 antibody; OTTHUMP00000016507 antibody; OTTHUMP00000016508 antibody; OTTHUMP00000016509 antibody; OTTHUMP00000016510 antibody; OTTHUMP00000016511 antibody; OTTHUMP00000016512 antibody; S29A1_HUMAN antibody; Slc29a1 antibody; solute carrier family 29 (equilibrative nucleoside transporter), member 1 antibody; solute carrier family 29 (nucleoside transporters), member 1 antibody; Solute carrier family 29 member 1 antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human,Mouse,Rat
-
免疫原：Human ENT1
-
免疫原種屬：Homo sapiens (Human)
-
抗體亞型：IgG
-
純化方式：Antigen Affinity Purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA,WB,IHC
-
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
-
基因功能參考文獻(xiàn)：
- CD73-depedent elevation of plasma adenosine signaling via ADORA2B-mediated protein kinase A phosphorylation, ubiquitination and proteasome degradation of erythrocyte ENT1 is a novel feed-forward signaling network underlying initial hypoxic adaptation and retention upon re-exposure. PMID: 28169986
- FBW7 promoted gemcitabine sensitivity via upregulation of equilibrative nucleoside transporter 1 (ENT1) at the protein level rather than the transcriptional level. PMID: 28765935
- ENT1 is a prognostic marker for pT2 gallbladder cancer (GBC) patients. PMID: 26266900
- FLT3 has a role in cytarabine transport by SLC29A1 in pediatric acute leukemia PMID: 27391351
- rs760370 SNP cannot serve as predictor of response in chronic HCV patients treated with interferon ribavirin therapy. PMID: 28207300
- Glycosylation at N48 is critical for the localization, function and oligomerization of hENT1. PMID: 27480168
- The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102. PMID: 28992563
- CYR61 negatively regulates the nucleoside transporters hENT1 and hCNT3 in pancreatic ductal adenocarcinoma. PMID: 27604902
- Chronic inhibition of ENT1 or by genetic removal of ENT1 enhanced the survival of R6/2 mice. Collectively, adenosine homeostasis and ENT1 expression are altered in Huntington's disease (HD). The inhibition of ENT1 can enhance extracellular adenosine level and be a potential therapeutic approach for treating HD. PMID: 28069792
- hENT1 expression could predict gemcitabine efficacy in leiomyosarcoma and angiosarcoma patients, and if confirmed in prospective trials, these data would allow a better patient selection and an improvement in therapeutic efficacy. PMID: 28641307
- studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation. PMID: 27694321
- Binding of hENT1 to adenosine, deoxyadenosine, and adenine by isothermal titration calorimetry is in general agreement with results of the competitive inhibition assays. These results validate hENT1 as a bona fide target for potential drug target and serve as a useful basis for future biophysical and structural studies. PMID: 27995448
- These findings suggest that ENT1 is regulated via receptor-dependent calcium-linked pathways resulting in an alteration of purine flux, which may modulate purinergic signaling and influence NA drug efficacy. PMID: 27009875
- SLC29A1 rs760370 and KLF12 rs9543524 SNPs are associated with treatment induced thrombocytopenia in chronic hepatitis C patients treated with PEGIFN2b/ribavirin/combination. PMID: 26750805
- interaction of Met(33) (involved in dipyridamole binding) with BCR-ABL inhibitors and reduced interaction with M33A mutant hENT1. PMID: 27432881
- Authors clearly demonstrate that ribavirin uptake in primary human hepatocytes is variable and correlates with ENT1 expression. PMID: 28417642
- A pro-apoptotic effect of verapamil was observed in L3.6pl cells, but not in L3.6plGres cells, which was linked to their differential expression of P-gp and equilibrative nucleoside transporter-1 (ENT-1). PMID: 27177126
- Human ENT1 proteins exist as two sub-populations, and cytidine pre-treatment leads to the internalization of one population. PMID: 27906634
- The mRNA expression levels of the human equilibrative transporter-1 (hENT1) were significantly down-regulated under hypoxia, but treatment with NHI-1 was associated with a recovery of hENT1 expression. PMID: 27906635
- Results showed that both SLC29A1 and SLC29A2 were expressed at lower levels in colon cancer cell lines originating from metastatic sites than from primary sites. PMID: 28218790
- Direct evidence for apical localization of ENT1 and integral expression of ENT2 in intestinal epithelial cells. PMID: 27160886
- mRNA expression of ENT1 was closely associated with cell proliferation and varied in seven non-Hodgkin lymphoma cell lines. PMID: 27173327
- Data show that equilibrative nucleoside transporter (hENT1) expression was an independent prognostic factor in both whole patients and those with resection. PMID: 26784908
- Low ENT1 expression is associated with periampullary adenocarcinoma. PMID: 26362587
- High expression of hENT1 appears to predict a good response to decitabine and a prolonged survival in higher-risk myelodysplastic syndrome patients treated with decitabine. PMID: 26944860
- Studies indicate that an autophagy response induced by hepatitis C virus (HCV) in a cell culture reduces ribavirin (RBV) uptake and antiviral activity by diminishing the surface expression of nucleoside transporters) member 1 (ENT1). PMID: 26431496
- The identification of ITPA protective and SLC29A1 risk genotypes still appears to be a current methodology in Ribavirin dosing during hepatitis C virus therapy with direct acting antiviral agents PMID: 26279293
- The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters. PMID: 26406980
- RECPAM analysis showed that DCK and CHOP were most relevant variables for the identification of patients with different mortality risk, while hENT1 and CHOP were able to identify subgroups of patients with different disease progression risk PMID: 25199538
- ENT1 expression profile did not serve as a useful prognostic biomarker and therapeutic target for surgically resected patients with ampullary carcinoma. PMID: 25906447
- Adenosine A1 receptor activation increases ENT1 activity via protein kinase C. PMID: 25725289
- Brains from patients with drug-resistant temporal lobe epilepsy had higher levels of ENT1 than controls. PMID: 25490964
- Acute myeloid leukemia patients with low activity of SLC29A1 genotype have shorter disease-free and overall survival in Ara-C based therapy. PMID: 25398670
- SNPS in SLC29A1 were not associated with increased risk of post-traumatic epilepsy development after brain injury. PMID: 26040919
- results establish Augustine as a new blood group system and place SLC29A1 as a new candidate gene for idiopathic disorders characterized with ectopic calcification/mineralization. PMID: 25896650
- Human equilibrative nucleoside transporter 1c1 and d3 (and c2) mRNAs are primarily expressed in human hepatocytes, which suggests that they may play important roles in controlling hENT1 expression levels in those cells. PMID: 24522200
- meta-analysis suggests that high hENT1 expression may be associated with improved OS and DFS of pancreatic cancer patients treated with gemcitabine PMID: 24625353
- High intratumoural hENT1 and low RRM1 expression were independently associated with prolonged disease-free survival in cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy. PMID: 25032731
- Study found no evidence supporting the use of hENT1 as a predictive biomarker for gemcitabine efficacy in patients with advanced pancreatic cancer. PMID: 24857044
- A low human equilibrative nucleoside transporter1 level represents a significant and reproducible marker of adverse prognosis in pancreatic cancer receiving gemcitabine-based chemotherapy. PMID: 24475233
- potential prognostic and predictive role of SLC29A1 has been demonstrated for selected subset of patients--{REVIEW} PMID: 24280569
- Studies indicate that high expression of nucleoside transporter subunits 1 (hENT1) in pancreaticobiliary (PB) cancer patients receiving GEM-based adjuvant therapy is associated with improved overall survival and disease-free survival. PMID: 24152955
- Genetic polymorphisms in SLC28A3, SLC29A1 and RRM1 can influence the clinical outcome of metastatic breast cancer patients treated with paclitaxel-gemcitabine chemotherapy. PMID: 24361227
- findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury PMID: 23703920
- Studies indicate that HENT1 and SPARC expression seem to be useful predictive factors of response to chemotherapy in pancreatic cancer. PMID: 23846918
- these findings reveal the transcriptional repression of ENT1,2 as an innate protective response during acute pulmonary inflammation. PMID: 23590299
- hENT1 and Notch3 mRNA expressions in biopsy specimens were the key predictive biomarkers of gemcitabine effect and gemcitabine sensitivity in patients with unresectable pancreatic ductal carcinoma. PMID: 23492684
- Data suggest that SLC29A1 is located on basolateral membrane of adult Sertoli cells; SLC29A1 is primarily responsible for basolateral nucleoside uptake into Sertoli cells. In contrast, SLC29A2 is localized to apical membrane of Sertoli cells. PMID: 23639800
- It was confirmed that wild-type for single nucleotide polymorpismss rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in peripheral blood mononuclear cells. PMID: 23095574
- ENT1-mediated uptake of gemcitabine might compensate for the total uptake of gemcitabine; therefore, the variation in the apparent accumulation of gemcitabine is smaller than that of the individual transporters. PMID: 22644860
顯示更多
收起更多
-
亞細(xì)胞定位：Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.
-
蛋白家族：SLC29A/ENT transporter (TC 2.A.57) family
-
組織特異性：Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
-
-
-
-
-
