SLC25A46 Antibody
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中文名稱：SLC25A46兔多克隆抗體
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貨號：CSB-PA856895LA01HU
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規格：￥440
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圖片：
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Western blot
All lanes: SLC25A46 antibody at 6µg/ml
Lane 1: Mouse brain tissue
Lane 2: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47, 31, 38 kDa
Observed band size: 47 kDa -
Immunofluorescent analysis of Hela cells using CSB-PA856895LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLC25A46 Polyclonal antibody
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Uniprot No.：
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基因名：SLC25A46
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別名：SLC25A46; TB1; Solute carrier family 25 member 46
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human Solute carrier family 25 member 46 protein (1-102AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，SLC25A46 Antibody (CSB-PA856895LA01HU)，的標記方式是Non-conjugated。對于SLC25A46 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.
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基因功能參考文獻：
- This study reported a novel variant (p.Trp160Ser) in SLC25A46 and we broaden the phenotypic spectrum associated with mutations in SLC25A46. PMID: 28558379
- This study identified of a homozygous missense mutation c.1022T>C and a homozygous genomic deletion involving exon 1 in SLC25A46 encoding a mitochondrial protein leading to lethal pontocerebellar hypoplasia with apnoea and profound weakness. PMID: 27543974
- These results show that SLC25A46 plays a role in a mitochondrial/endoplasmic reticulum pathway that facilitates lipid transfer, and link altered mitochondrial dynamics to early-onset neurodegenerative disease and cell fate decisions. PMID: 27390132
- SLC25A46 is selectively degraded from the outer membrane independently of mitophagy and apoptosis, providing a framework for mechanistic studies in the proteolysis of outer membrane proteins PMID: 28057766
- we showed that the Slc25a46 disruption caused a fusion/fission imbalance and an abnormal mitochondrial architecture that disturbed mitochondrial metabolism. These data extended the range of phenotypes associated with Slc25a46 dysfunction. Moreover, this Slc25a46 knock-out mouse model should be useful to further elucidate the role of SLC25A46 in mitochondrial dynamics PMID: 28376083
- Our mutant mice provide a valid model for understanding the mechanistic basis of the complex SLC25A46-mediated pathologies, as well as for screening potential therapeutic interventions. PMID: 28376086
- The rs10056340 single nucleotide polymorphism was significantly associated with atopic dermatitis. PMID: 26464032
- Data indicate four families with recessive mutations in solute carrier family 25 member 46 protein (SLC25A46). PMID: 26168012
- Rs17132261 was associated with left ventricular hypertrophy in type 2 diabetic patients. PMID: 23879873
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相關疾病：Neuropathy, hereditary motor and sensory, 6B (HMSN6B)
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亞細胞定位：Mitochondrion outer membrane; Multi-pass membrane protein.
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蛋白家族：Mitochondrial carrier (TC 2.A.29) family
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數據庫鏈接：
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