SLC24A5 Antibody

Name: SLC24A5 Antibody
Brand: CUSABIO
SKU: CSB-PA754654LA01HU

說(shuō)明書(shū)

中文名稱：

SLC24A5兔多克隆抗體
貨號(hào)：

CSB-PA754654LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate
All lanes: SLC24A5 antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55, 49 kDa
Observed band size: 55 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SLC24A5 Polyclonal antibody
Uniprot No.：

Q71RS6
基因名：

SLC24A5
別名：

Ion transporter JSX antibody; JSX antibody; Na(+)/K(+)/Ca(2+)-exchange protein 5 antibody; NCKX5 antibody; NCKX5_HUMAN antibody; Slc24a5 antibody; Sodium/potassium/calcium exchanger 5 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger),member 5 antibody; Solute carrier family 24 member 5 antibody; Solute carrier family 24,member 5 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Sodium/potassium/calcium exchanger 5 protein (240-298AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，SLC24A5 Antibody (CSB-PA754654LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SLC24A5 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA754654LB01HU	SLC24A5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA754654LC01HU	SLC24A5 Antibody, FITC conjugated
Biotin	CSB-PA754654LD01HU	SLC24A5 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+).
基因功能參考文獻(xiàn)：
1. both polymorphisms (rs1426654 and rs2470102) play an important role in the skin pigmentation diversity of South Asians PMID: 27866970
2. Letter/Case Report: OCA6 mutation in 6 year old boy with oculocutaneous albinism. PMID: 26686029
3. mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients. PMID: 27129268
4. a novel homozygous mutation in SLC24A5 in two patients from French Guiana strengthens the importance of screening this gene in oculocutaneous albinism patients. PMID: 26491832
5. the SLC24A5 gene locus known to be associated with skin pigmentation was in the top selection signals in the Wolaita, and the alleles of single-nucleotide polymorphisms rs1426654 and rs1834640 (SLC24A5) associated with light skin pigmentation PMID: 25370040
6. Polymorphisms of SLC24A5 were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population, considered useful in forensic science for crime investigation and facial reconstruction in unknown bodies. PMID: 25801600
7. All chromosomes carrying the A111T allele of SLC24A5 gene share a single 78-kb haplotype indicating that all instances of this mutation in human populations share a common origin. PMID: 24048645
8. Sequencing 11.74 kb of SLC24A5 in 95 individuals worldwide reveals that the rs1426654-A alleles in South Asian and West Eurasian populations are monophyletic and occur on the background of a common haplotype that is characterized by low genetic diversity PMID: 24244186
9. We observed a heterogeneous phenotype among seven oculocutaneous albinism patients with SLC24A5 mutations. PMID: 23985994
10. SLC24A5 is a previously unreported nonsyndromic oculocutaneous albinism candidate gene. PMID: 23364476
11. NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes. PMID: 23224873
12. Observational study of gene-disease association. (HuGE Navigator) PMID: 20691427
13. the variant allele is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation PMID: 16357253
14. The p.L374F allele in SLC45A2 is a more specific ancestry informative marker than the p.A111T allele in SLC24A5, as it clearly distinguishes Sri Lankans from Europeans. PMID: 16847698
15. non-synonymous single nucleotide polymorphism in SLC24A5 alters a residue that is important for NCKX5 and NCKX2 activity PMID: 18166528
16. Greek subjects showed a prevalence of the Thr(111) allele variant of the SLC24A5 gene, even among subjects with darker skin pigmentation or phototype. PMID: 18637132
17. higher tyrosinase protein abundance was not observed for any NCKX5-111 allele variation PMID: 18650849
18. Observational study of gene-disease association. (HuGE Navigator) PMID: 19944766
19. Observational study of gene-disease association. (HuGE Navigator) PMID: 19384953
20. Observational study of gene-disease association. (HuGE Navigator) PMID: 19336370
21. Observational study of gene-disease association. (HuGE Navigator) PMID: 19060277
22. Observational study of gene-disease association. (HuGE Navigator) PMID: 18637132
23. Observational study of gene-disease association. (HuGE Navigator) PMID: 17999355
24. The NCKX5 protein, encoded by the SLC24A5 gene, is localized to the trans-Golgi network where it may influence melanosomal assembly. The SLC24A5 allele encoding threonine-111 confers reduced NCKX5 activity. PMID: 18166528
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相關(guān)疾病：

Albinism, oculocutaneous, 6 (OCA6)
亞細(xì)胞定位：

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes (PubMed:17081065).
蛋白家族：

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
數(shù)據(jù)庫(kù)鏈接：

HGNC: 20611

OMIM: 113750

KEGG: hsa:283652

STRING: 9606.ENSP00000341550

UniGene: Hs.710240

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