SLC16A11 Antibody

中文名稱：

SLC16A11兔多克隆抗體
貨號：

CSB-PA843323LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate
All lanes: SLC16A11 antibody at 3.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa

Immunofluorescence staining of A549 cells with CSB-PA843323LA01HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC16A11 Polyclonal antibody
Uniprot No.：

Q8NCK7
基因名：

SLC16A11
別名：

FLJ90193 antibody; MCT 11 antibody; Monocarboxylate transporter 11 antibody; MOT11_HUMAN antibody; SLC16A11 antibody; Solute carrier family 16 member 11 (monocarboxylic acid transporter 11) antibody; Solute carrier family 16 member 11 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Monocarboxylate transporter 11 protein (428-471AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SLC16A11 Antibody (CSB-PA843323LA01HU)，的標記方式是Non-conjugated。對于SLC16A11 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA843323LB01HU	SLC16A11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA843323LC01HU	SLC16A11 Antibody, FITC conjugated
Biotin	CSB-PA843323LD01HU	SLC16A11 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
基因功能參考文獻：
1. rs13342232 might be involved in the risk of pediatric-onset type 2 diabetes in Mexican families PMID: 28101933
2. Study demonstrates that disruption of SLC16A11 in primary human hepatocytes leads to Type 2 diabetes (T2D)-relevant changes in fatty acid and lipid metabolism; these results implicate reduced SLC16A11 function in liver as a causal factor for T2D. PMID: 28666119
3. Our study identified an association between the SLC16A11 variant rs75493593 and type 2 diabetes in American Indians, where the effect on diabetes was much more pronounced in nonobese individuals. rs75493593 was also associated with RNASEK gene expression. PMID: 26487785
4. Genetic association studies show that common variants in ABCA1 and SLC16A11 are involved in type 2 diabetes (T2D) susceptibility. Particularly, the variants rs10811661 (CDKN2A/2B) and rs9282541 (ABCA1) are associated with T2D in adult Maya population. PMID: 25839936
5. Despite type 2 diabetes having been well studied by GWAS in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism. PMID: 24390345
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相關疾病：

Diabetes mellitus, non-insulin-dependent (NIDDM)
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
組織特異性：

Expressed in liver, salivary gland and thyroid.
數據庫鏈接：

HGNC: 23093

OMIM: 125853

KEGG: hsa:162515

STRING: 9606.ENSP00000310490

UniGene: Hs.336564

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