SLC13A3 Antibody
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中文名稱：SLC13A3兔多克隆抗體
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貨號：CSB-PA798619
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規格：￥1100
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圖片：
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, Human plasma tissue, Primary antibody: CSB-PA798619(SLC13A3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：dicarboxylate cotransporter 3 antibody; H sapiens mRNA for hepatocyte nuclear factor 4 gamma antibody; hNaDC3 antibody; Na antibody; Na(+)/dicarboxylate cotransporter 3 antibody; NaDC 3 antibody; NaDC-3 antibody; NADC3 antibody; S13A3_HUMAN antibody; SDCT 2 antibody; SDCT2 antibody; SLC13A3 antibody; Sodium dependent high affinity dicarboxylate transporter 2 antibody; Sodium dependent high affinity dicarboxylate transporter 3 antibody; Sodium-dependent high-affinity dicarboxylate transporter 2 antibody; Solute carrier family 13 (sodium dependent dicarboxylate transporter); member 3 antibody; Solute carrier family 13 member 3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human SLC13A3
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
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基因功能參考文獻：
- NaDC3-related immunostaining was detected in the basolateral membrane of proximal tubules and in the basolateral membrane and/or luminal membrane of principal cells in connecting segments and collecting ducts PMID: 27053689
- OAT1 and NaDC3 in the basolateral membrane and OAT4 in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate. PMID: 25354943
- In a study addressing genetic, social, and environmental contributors of chronic kidney disease with tubulointerstitial damages in Sri Lanka, SNP rs6066043 of SLC13A3 was found attributable risk of 50%. PMID: 24351856
- study concludes NaDC3 present at the basolateral membrane of proximal tubule cells mediates sodium-dependent glutathione (GSH) uptake; the kinetic data show that NaDC3 is a low-affinity GSH transporter PMID: 24247155
- The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3 PMID: 21865262
- The results indicate that SLC13A3 is a direct downstream target of PITX2 transcriptional regulation and that levels of PITX2 and SLC13A3 modulate responses to oxidative stress in ocular cells. PMID: 21873665
- NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1. PMID: 20813124
- The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 or 3. PMID: 15561973
- We provide direct evidence of the localization of NaDC3 at the basolateral membrane of human renal proximal tubule cells and identify a di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain of NaDC3. PMID: 16331647
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：SLC13A/DASS transporter (TC 2.A.47) family, NADC subfamily
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組織特異性：Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.
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數據庫鏈接：
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