SLC10A1 Antibody
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中文名稱：SLC10A1兔多克隆抗體
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貨號：CSB-PA005605
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規格：￥1090
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圖片：
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Western Blot analysis of A549 cells using NTCP Polyclonal Antibody.
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Cell growth-inhibiting gene 29 protein antibody; GIG29 antibody; Growth inhibiting protein 29 antibody; Na / bile acid cotransporter antibody; Na / taurocholate transport protein antibody; Na(+)/bile acid cotransporter antibody; Na(+)/taurocholate transport protein antibody; Na/taurocholate cotransporting polypeptide antibody; NTCP antibody; NTCP_HUMAN antibody; NTCP1 antibody; SLC10A1 antibody; Sodium/bile acid cotransporter antibody; Sodium/taurocholate cotransporter polypeptide, hepatic antibody; Sodium/taurocholate cotransporting polypeptide antibody; Solute carrier family 10 (sodium/bile acid cotransporter family) member 1 antibody; Solute carrier family 10 member 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the C-terminal region of Human NTCP.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.; (Microbial infection) Acts as a receptor for hepatitis B virus.
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基因功能參考文獻：
- we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research PMID: 30097692
- In this study, the authors identified new hepatitis B virus isolates from one homozygous S267F NTCP mutation carrier and confirmed new isolates also use wildtype-NTCP as a cellular receptor. Furthermore, we demonstrated S267F variant of NTCP, though inefficient, is still a functional receptor for hepatitis B virus entry. PMID: 30032030
- These findings suggest that host factors unique to HepaRG cells are required for efficient infection by serum-derived HBV, and factors other than NTCP contribute to balanced viral antigen production following infection by cell culture-derived HBV. PMID: 29793953
- These kinetic results provide important complementary data on the substrate selectivity and specificity of NTCP to transport bile acids. PMID: 29024779
- Results show that NTCP inhibition suppressed the in vivo spread of HBV infection in the presence of uninfected hepatocytes. Livers in CHB patients contained varying degrees of HBsAg-negative hepatocytes, as evidenced by immunohistochemistry. PMID: 27278060
- These results uncover NTCP as a mediator of innate antiviral immune responses in the liver. PMID: 27783949
- For Tibetans and Uygurs, no association of the three NTCP SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with hepatitis B virus chronicity was observed. PMID: 27051045
- the present study indicated that the common variants in the regulatory elements of NTCP may not influence the expression level of SLC10A1 at transcriptional regulation, and ultimately may not be associated with HBV susceptibility. PMID: 27491457
- The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population. PMID: 28125961
- The SLC10A1 (NTCP) S267F variant is independently associated with decreased risk of progression to Liver cirrhosis and Hepatocellular Carcinoma , and resistance to Chronic Hepatitis B infection. PMID: 26642861
- In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus. PMID: 27384660
- Computer screening of NTCP inhibitors and non-inhibitors showed no relationship between the drugs and drug induced liver injury. PMID: 25220493
- We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese PMID: 26968990
- The observation that the pharmacological inhibitors of the NTCP transporter could block HBV entry suggests that NTCP represents an attractive molecular target for therapeutic intervention in HBV infection. PMID: 25929767
- Hepatitis B virus efficiently infects non-adherent hepatoma cells via NTCP, which functions as a virus receptor. PMID: 26592202
- We describe for the first time a mouse liver cell line that, solely upon expression of the hNTCP receptor, becomes susceptible to HBV. PMID: 26865711
- This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection. PMID: 25010264
- Liver nuclear receptors, FXR and SHP, and bile acid transporters, NTCP and BSEP, are associated with the progression of NAFLD. PMID: 26019035
- Interleukin 6 inhibits HBV entry through downregulation of NTCP. PMID: 25765005
- NTCP is a functional receptor for hepatitis B virus and hepatitis D virus. PMID: 25409679
- NTCP polymorphism play a critical role in the individual variability of rosuvastatin pharmacokinetics in Chinese healthy males PMID: 25985569
- NTCP is a functional receptor for human hepatitis B and D virus. PMID: 23150796
- hNTCP is an electrogenic Na(+)-dependent transporter PMID: 25168282
- findings suggest that the rs2296651 polymorphism in NTCP may predispose the susceptibility to and chronicity of HBV infection PMID: 24735529
- Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on NTCP. PMID: 24390325
- Human NTCP is a specific receptor for hepatitis B and D viruses, allowing virus entry into hepatocytes. PMID: 24361467
- Polymorphisms in CYP2C9, CYP2C19 and SLC10A1 had minimal lipid-lowering effects. PMID: 23930675
- Knockdown analysis suggested that HBV infection of HepG2-hNTCP-C4 cells was mediated by NTCP. PMID: 24342612
- This study was conducted to determine which of the 8 cysteine residues of NTCP is responsible for nitric oxide-mediated S-nitrosylation and inhibition of taurocholate uptake. PMID: 23886862
- Data suggest that, in SLC10A1, amino acid residues along one face of transmembrane domain 5 do not play direct role in substrate transport but are critical for sodium/bile acid transport functions of SLC10A1, most likely through helical stability. PMID: 23815591
- these results suggest that the plasma membrane localization rather than kinase activity of PKCdelta plays an important role in cAMP-induced NTCP translocation and Rab4 activity PMID: 22744337
- Patients undergoing partial hepatectomy with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre. PMID: 22098322
- NTCP adopts a dimeric structure in which individual subunits are functional. Bile salt uptake is influenced by heterodimerization when this impairs NTCP plasma membrane trafficking. PMID: 22029531
- essential role of Na+-taurocholate co-transporting polypeptide (NTCP) in the uptake of bile acids, by which the enterohepatic recirculation of bile acids is maintained PMID: 21341987
- Inhibition of taurocholate uptake by nitric oxide involves S-nitrosylation of NTCP. PMID: 21109590
- The mRNA expression levels of sodium taurocholate cotransporting polypeptide, bile salt export pump, and hepatic cholesterol 7alpha-hydroxylase were significantly higher in the primary biliary cirrhosis patients than in the controls. PMID: 20857261
- Translation/insertion scanning, alanine insertion, and glycosylation site mutagenesis studies of liver sodium/bile acid cotransporter support a topography with nine membrane-spanning or membrane-associated segments. PMID: 12044156
- a domain critical for bile acid substrate recognition of SLC10A1 has an ethnicity-dependent polymorphism PMID: 14660639
- Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner. Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression. PMID: 14701722
- The present studies were undertaken to establish a suitable in vitro experimental model to study human ASBT function and its regulation by cholesterol. PMID: 15604201
- The major canalicular transporter genes are expressed at mid-gestational stage during human fetal development. PMID: 15922475
- Results suggest that the Ser-226 in the third cytoplasmic loop of NTCP is phosphorylated and cAMP may increase NTCP translocation to the cell membrane by dephosphorylating NTCP at this site. PMID: 16027164
- The GR/dexamethasone activation of the hNTCP promoter is counteracted by bile acids and small heterodimer partner, providing a negative feedback mechanism for bile acid uptake in human hepatocytes. PMID: 16123152
- Cholesterol treatment led to increased levels of NTCP and OCT-1 mRNAs. PMID: 17635184
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亞細胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：Bile acid:sodium symporter (BASS) (TC 2.A.28) family
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