SHANK1 Antibody
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中文名稱：SHANK1兔多克隆抗體
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貨號：CSB-PA021247GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：GKAP/SAPAP interacting protein antibody; OTTHUMP00000174437 antibody; SH3 and multiple ankyrin repeat domains 1 antibody; SH3 and multiple ankyrin repeat domains protein 1 antibody; SH3/ankyrin domain gene 1 antibody; SHAN1_HUMAN antibody; SHANK 1 antibody; Shank1 antibody; Shank1a antibody; Somatostatin receptor interacting protein antibody; Somatostatin receptor-interacting protein antibody; SPANK 1 antibody; SPANK1 antibody; SSTR interacting protein antibody; SSTR-interacting protein antibody; SSTRIP antibody; Synamon antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human SHANK1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
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基因功能參考文獻：
- Authors summarize and discuss behavioral and neuronal findings obtained in the Shank1 knockout mouse model for Autism spectrum disorder (ASD); identify open research questions by comparing such findings with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions; conclude by discussing the implications of the behavioral and neuronal phenotypes displayed by the Shank1 knockout mouse model. PMID: 28963042
- SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. PMID: 28263956
- Data show that the Shank1 protein mRNA 3' UTR adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP). PMID: 25692235
- a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA PMID: 24533096
- The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia. PMID: 21901269
- A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning. PMID: 22503632
- Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1. PMID: 19416473
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亞細胞定位：Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
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蛋白家族：SHANK family
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組織特異性：Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
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數據庫鏈接：
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