SH3BP2 Antibody
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中文名稱：SH3BP2兔多克隆抗體
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貨號：CSB-PA021224LA01HU
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規(guī)格：￥440
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圖片：
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IHC image of CSB-PA021224LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SH3BP2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：3BP-2 antibody; 3BP2 antibody; 3BP2_HUMAN antibody; Abl SH3 binding protein 2 antibody; Cherubism antibody; CRBM antibody; CRPM antibody; FLJ42079 antibody; FLJ54978 antibody; RES4-23 antibody; SH3 domain binding protein 2 antibody; SH3 domain-binding protein 2 antibody; Sh3bp2 antibody; TNFAIP3 interacting protein 2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human SH3 domain-binding protein 2 protein (165-301AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，SH3BP2 Antibody (CSB-PA021224LA01HU)，的標記方式是Non-conjugated。對于SH3BP2 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:200-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
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基因功能參考文獻：
- All members featured a heterozygous missense c.1244G>C; p.Arg415Pro SH3BP2 mutation PMID: 28721660
- The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. PMID: 25810396
- A c.1244G>A (p.Arg415Gln) mutation in SH3BP2 gene causes cherubism in a Turkish family PMID: 24608212
- Authors conclude that a novel p.Asp419Tyr alteration in SH3BP2 to be a cherubism-causing mutation in a Turkish family. PMID: 23083484
- In the first family, a missense mutation Arg415Gln was found in exon 9 of SH3BP2 in all affected individuals. The unaffected individuals did not have the mutation. In the second family, a missense mutation Pro418Thr was identified in exon 9 of the SH3BP2 PMID: 22795151
- These results demonstrate that PARP1 regulates expression of SH3BP2. PMID: 22820184
- P416R mutation of 3BP2 causes the gain of function in B cells by increasing the interaction with specific signaling molecules. PMID: 21794028
- if a primary genetic defect is the cause for CGCG it is either located in SH3BP2 gene exons not yet related to cherubism or in a different gene. PMID: 21680150
- The SH-3BP-2 mutation may participate in the differentiation and maturation of osteoclast-like cells in the lesion of cherubism. PMID: 19576004
- over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and PLCgamma2. PMID: 20872577
- No SH3BP2 gene mutation was found in PGCL. PMID: 20002873
- Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. PMID: 12200378
- 3BP2 may regulate b cell receptor-mediated gene activation through Vav proteins. PMID: 15345594
- Adaptor protein SH3BP2 regulates transcription factors through its tyrosine phosphorylation and SH2 domain. PMID: 15751964
- CD244-3BP2 association regulates cytolytic function but not IFN-gamma release PMID: 16177062
- no mutations...in giant cell granuloma PMID: 16713042
- How SH3BP2 affects leukocyte signaling and influences cherubism PMID: 16802602
- a novel A1517G missense mutation at the SH3BP2 gene in a Chinese family with multiple affected individuals with cherubism was identified PMID: 17147794
- Mutated in a rare human disease involved in cranial-facial development called cherubism, suggesting a role for 3BP2 in regulating osteoclast and hematopoietic cell function. [REVIEW] PMID: 17156730
- unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55 PMID: 17306257
- A new mutation in a family affected with cherubism PMID: 17321449
- People with Giant Cell Granuloma of the Jaw do not harbour cherubism-related germline SH3BP2 mutations. PMID: 17544554
- Point mutations in the SH3BP2 gene have been revealed in cherubism patients. PMID: 18596838
- 2 novel mutations were found; heterozygous missense mutation c.1442A>T (Q481L) in exon 11 in one sporadic case of CGCL and heterozygous germline and tumor tissue missense mutation c.320C>T (T107M) in exon 4 in one patient with cherubism. PMID: 19017279
- 3BP2 induces the protein complex with cellular signaling molecules through phosphorylation of Tyr(183) and SH2 domain leading to the activation of NFAT in B cells PMID: 19833725
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相關疾病：Cherubism (CRBM)
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組織特異性：Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
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數據庫鏈接：
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