SF3B3 Antibody
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中文名稱：SF3B3兔多克隆抗體
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貨號：CSB-PA008371
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：SF3B3
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別名：KIAA0017 antibody; Pre mRNA splicing factor SF3b 130 kDa subunit antibody; Pre-mRNA-splicing factor SF3b 130 kDa subunit antibody; RSE1 antibody; SAP 130 antibody; SAP130 antibody; SF3b130 antibody; SF3B3 antibody; SF3B3_HUMAN antibody; Spliceosome associated protein 130 antibody; Spliceosome-associated protein 130 antibody; Splicing factor 3b subunit 3 130kD antibody; Splicing factor 3B subunit 3 antibody; STAF130 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human SF3b130.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
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基因功能參考文獻(xiàn)：
- These results suggest SF3B3 as a key regulator of EZH2 pre-mRNA splicing and SF3B3 may represent a novel prognostic factor and potential therapeutic target in clear cell renal cell carcinoma PMID: 27879367
- our findings suggest a role for the elevated expression of SF3B3 in poor prognosis and tamoxifen resistance, leading to recurrence of estrogen receptor-positive breast cancer PMID: 25431237
- Report detection of SF3B3 gene mutations in oral cancer using high resolution melting analysis. PMID: 25651737
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亞細(xì)胞定位：Nucleus.
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蛋白家族：RSE1 family
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數(shù)據(jù)庫鏈接：
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