Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
基因功能參考文獻:
A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. PMID: 20451170
In mast cells, SERPINB6 serves to regulate the activity of endogenous beta-tryptase in the cytoplasm. PMID: 14670919
Expressed in developing gonads and in both somatic and germ cells of adult gonads. PMID: 16175637
Protects the intracellular compartment of keratinocytes from ectopic kallikrein-8. PMID: 17761692
the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502
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相關疾病:
Deafness, autosomal recessive, 91 (DFNB91)
亞細胞定位:
Cytoplasm.
蛋白家族:
Serpin family, Ov-serpin subfamily
組織特異性:
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissu