SERPINA4 Antibody

說明書

中文名稱：

SERPINA4兔多克隆抗體
貨號：

CSB-PA005146
規格：

￥1090
圖片：
Western Blot analysis of K562 cells using Kallistatin Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P29622
基因名：

SERPINA4
別名：

KAIN_HUMAN antibody; KAL antibody; Kallikrein binding protein antibody; Kallikrein inhibitor antibody; Kallistatin antibody; KBP antibody; KLST antibody; KST antibody; MGC108582 antibody; Peptidase inhibitor 4 antibody; PI-4 antibody; PI4 antibody; Protease inhibitor 4 (kallistatin) antibody; Protease inhibitor 4 antibody; Serine (or cysteine) proteinase inhibitor; clade A (alpha 1 antiproteinase; antitrypsin); member 4 antibody; Serpin A4 antibody; Serpin peptidase inhibitor clade A member 4 antibody; Serpin peptidase inhibitor; clade A (alpha 1 antiproteinase; antitrypsin); member 4 antibody; SERPINA4 antibody; Tissue kallistatin inhibitor antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Kallistatin.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
基因功能參考文獻：
1. Kallistatin levels may provide useful information regarding cardiovascular risk in women with polycystic ovary syndrome PMID: 28294594
2. Kallistatin functions as an endogenous lymphangiogenesis inhibitor and has an important part in the lymphatic metastasis of gastric cancer.Kallistatin was reduced in the cancer tissue and plasma of gastric cancer patients. PMID: 29243194
3. SNPs rs2093266 in the SERPINA4 is associated with the development of severe acute kidney injury (KDIGO stage 2-3) in critically ill patients with septic shock PMID: 28270177
4. oxidative stress induces down- or upregulation of kallistatin expression, depending on oxygen concentration, and kallistatin plays a novel role in mediating oxygen/exercise-induced HIF-1-eNOS-NO pathway. PMID: 29387292
5. These findings reveal novel mechanisms of kallistatin in protection against senescence, aging, and cancer development by modulating miR-34a and miR-21 levels and inhibiting oxidative stress. PMID: 28744338
6. These findings suggested that kallistatin may be a promising agent that could be used to suppress cancer metastasis by inhibiting both angiogenesis and lymphangiogenesis. PMID: 28440474
7. generated a meta-marker model made up of SERPINA4 and PON1 that is useful as a differential diagnostic biomarker differentiating lung cancer from other lung diseases. PMID: 27168012
8. The kallistatin's dual roles in angiogenesis, apoptosis and oxidative stress contribute to its beneficial effects in various diseases. PMID: 28742513
9. Our results indicate that during severe sepsis and septic shock, a decrease in plasma concentrations of kallistatin reflects increased severity and poorer outcome of disease. PMID: 28542440
10. data suggest that overexpression of kallistatin interferes with lymphopoiesis, ultimately impacting the level of circulating CD19(+) B lymphocytes. PMID: 28299632
11. Kallistatin levels were correlated with some markers of systemic inflammation in the HIV population. PMID: 27326658
12. Increased kallistatin levels in type 1 diabetes and its relation with carotid intima media thickness may reflect vascular dysfunction and suggest a link between micro- and macro-angiopathy. PMID: 26091968
13. reveal novel mechanisms of kallistatin in inducing apoptosis and autophagy in breast cancer cells PMID: 26790955
14. crystal structure of kallistatin 1.9 A resolution PMID: 26323298
15. Kallistatin protects against renal ischemia-reperfusion injury by blocking oxidative stress and renal inflammation. PMID: 25654330
16. Plasma kallistatin is a novel marker for severe community-acquired pneumonia prognosis. PMID: 23394256
17. decreased SPTBN1 and kallistatin gene expression associated with decreased relapse-free survival in hepatocellular carcinoma PMID: 25307947
18. these findings added the knowledge for us to understand the anti-angiogenic mechanism of kallistatin, which suggested that the rhKal could be worth as a candidate compound for further development for the purpose of anti-angiogenic therapies PMID: 24129914
19. A novel role of kallistatin in preventing breast tumor growth and mobility by direct interaction with LRP6. PMID: 23666756
20. As a potent antioxidant and anti-inflammation agent, kallistatin may also hold therapeutic promise in cardiometabolic disorders. PMID: 23190873
21. Genotyping reveals two single nucleotide polymorphisms in the BCL2 gene and a single nucleotide polymorphism in the SERPINA4 gene associated with a decreased risk of developing acute kidney injury. PMID: 22710204
22. Systemic administration of lentiviral vectors encoding kallistatin inhibited the growth of metastatic lung tumors and prolonged the survival of tumor-bearing mice. PMID: 20509975
23. Delivery of human kallistatin cDNA to ischemic rat hindlimb and breast tumor xenografts showed that Kallistatin is a new inhibitor of angiogenesis and tumor growth. PMID: 12384424
24. Results indicate that the heparin-binding domain, but not the reactive site loop of kallistatin, is essential for inhibiting vascular endothelial growth factor-induced angiogenesis. PMID: 12734113
25. KBP reduces expression of VEGF and HIF-1alpha nuclear translocation PMID: 17714861
26. Adeno-associated virus-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells. PMID: 17729417
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亞細胞定位：

Secreted.
蛋白家族：

Serpin family
組織特異性：

Expressed by the liver and secreted in plasma.
數據庫鏈接：

HGNC: 8948

OMIM: 147935

KEGG: hsa:5267

STRING: 9606.ENSP00000298841

UniGene: Hs.719893

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