SENP8 Antibody

中文名稱：

SENP8兔多克隆抗體
貨號：

CSB-PA822251HA01HU
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SENP8 Polyclonal antibody
Uniprot No.：

Q96LD8
基因名：

SENP8
別名：

cysteine 2 antibody; DEN 1 antibody; DEN1 antibody; Deneddylase 1 antibody; Deneddylase-1 antibody; FKSG8 antibody; HsT17512 antibody; NEDD 8 specific protease 1 antibody; NEDD8 specific protease cysteine 2 antibody; NEDD8-specific protease 1 antibody; NEDP 1 antibody; NEDP1 antibody; Protease antibody; Protease,聽cysteine聽2 antibody; PRSC2 antibody; SENP8 antibody; SENP8_HUMAN antibody; Sentrin / SUMO specific protease SENP 8 antibody; Sentrin-specific protease 8 antibody; Sentrin/SUMO-specific protease SENP8 antibody; SUMO sentrin specific protease family member 8 antibody; SUMO/sentrin peptidase family member; NEDD8 specific antibody; SUMO/sentrin specific peptidase family member 8 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Sentrin-specific protease 8 protein (1-212AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，SENP8 Antibody (CSB-PA822251HA01HU)，的標(biāo)記方式是Non-conjugated。對于SENP8 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA822251HB01HU	SENP8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA822251HC01HU	SENP8 Antibody, FITC conjugated
Biotin	CSB-PA822251HD01HU	SENP8 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
基因功能參考文獻(xiàn)：
1. Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells. PMID: 28475037
2. In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8. PMID: 25655932
3. Data indicate that overexpression of SENP8, a NEDD8-specific cysteine protease, resulted in deNEDDylation of E2F1 and promoted its transactivation activity at the p73 gene. PMID: 23001041
4. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells. PMID: 23408908
5. A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches. PMID: 23209320
6. the specificity of NEDD8-specific peptidase SENP8 PMID: 22110750
7. Data show that the stability of MDM2 is regulated by NEDD8 pathway and identify NEDP1 that deneddylates MDM2, resulting in MDM2 destabilization concomitant with p53 activation. PMID: 19784069
8. NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes PMID: 12730221
9. results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 by Nedd8 protein PMID: 12759363
10. X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis PMID: 15567417
顯示更多

收起更多
蛋白家族：

Peptidase C48 family
組織特異性：

Broadly expressed, with highest levels in kidney and pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 22992

OMIM: 608659

KEGG: hsa:123228

STRING: 9606.ENSP00000340505

UniGene: Hs.513002

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human