SEMA4C Antibody
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中文名稱：SEMA4C兔多克隆抗體
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貨號：CSB-PA863177DSR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA863177DSR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA863177DSR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SEMA4C Polyclonal antibody
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Uniprot No.：
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基因名：SEMA4C
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別名：KIAA1739 antibody; M-SEMA-F antibody; S4c antibody; SEM4C_HUMAN antibody; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C antibody; SEMA4C antibody; SEMACL1 antibody; SEMAF antibody; SEMAI antibody; Semaphorin-4C antibody; UNQ5855/PRO34487 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Semaphorin-4C protein (749-833AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
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基因功能參考文獻：
- Tumor-associated LECs produce sSEMA4C to promote lymphatic metastasis of tumors. PMID: 27401250
- ectopic expression of miR-25-3p reversed the epithelial-mesenchymal transition phenotype and sensitized cisplatin-resistant cervical cancer cells to cisplatin via targeting Sema4C PMID: 27743413
- Data show that G-protein-coupled receptor kinase-interacting protein 1 (GIT1) and semaphorin 4C (SEMA4C) were found to have putative microRNA miR-138 binding sites in their 3' untranslated region (3'UTRs). PMID: 26283050
- Suggest that up-regulation of miR-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers. PMID: 25605244
- Data suggest that Erbin can interact with Sema4C, and co-expression of Erbin blocks the process of Sema4C-induced epithelial-mesenchymal transition. PMID: 24142719
- There is a high expression of Sema4C in esophageal cancer, gastric cancer and rectal cancer, and expression is strongly correlated with lymphatic metastasis. PMID: 22944267
- High Sema4C is associated with epithelial-mesenchymal transition and renal fibrosis. PMID: 20959347
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亞細胞定位：Cell junction, synapse, postsynaptic density membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.
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蛋白家族：Semaphorin family
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數據庫鏈接：
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