SDCCAG3 Antibody

說明書

中文名稱：

SDCCAG3兔多克隆抗體
貨號：

CSB-PA265061
規格：

￥1100
圖片：
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA265061(SDCCAG3 Antibody) at dilution 1/235 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 2 minutes
其他：

產品詳情

Uniprot No.：

Q96C92
基因名：

SDCCAG3
別名：

ENTR1 antibody; SDCCAG3 antibody; Endosome-associated-trafficking regulator 1 antibody; Antigen NY-CO-3 antibody; Serologically defined colon cancer antigen 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human SDCCAG3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia. Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis.
基因功能參考文獻：
1. SDCCAG3 has a role in ciliogenesis and in localization of cargo to primary cilia PMID: 27767179
2. The novel endosomal protein SDCCAG3 forms a complex with PTPN13 & interacts with GIT1. Interaction of SDCCAG3 with PTPN13 is mediated by the PTPN13 FERM domain & the SDCCAG3 N-terminus. SDCCAG3 expression levels are elevated in colon cancers. PMID: 23108400
3. SDCCAG3 is important for protein trafficking and presentation of TNFR1 on the cell surface. PMID: 16332174
亞細胞定位：

Cytoplasm. Early endosome. Endosome. Recycling endosome. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
蛋白家族：

SDCCAG3 family
組織特異性：

Expressed in the colon (at protein level).
數據庫鏈接：

HGNC: 10667

KEGG: hsa:10807

STRING: 9606.ENSP00000349929

UniGene: Hs.94300

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