SCUBE1 Antibody

中文名稱：

SCUBE1兔多克隆抗體
貨號：

CSB-PA811616LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA811616LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SCUBE1 Polyclonal antibody
Uniprot No.：

Q8IWY4
基因名：

SCUBE1
別名：

SCUB1_HUMAN antibody; SCUBE 1 antibody; SCUBE1 antibody; Signal peptide, CUB and EGF-like domain-containing protein 1 antibody; Signal peptide, CUB domain, EGF like 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Signal peptide, CUB and EGF-like domain-containing protein 1 protein (453-566AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SCUBE1 Antibody (CSB-PA811616LA01HU)，的標記方式是Non-conjugated。對于SCUBE1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA811616LB01HU	SCUBE1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA811616LC01HU	SCUBE1 Antibody, FITC conjugated
Biotin	CSB-PA811616LD01HU	SCUBE1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
基因功能參考文獻：
1. The results of this pioneering study indicate that SCUBE protein family appears to have a probable role in the pathogenesis and angiogenesis development in psoriasis and SCUBE 1 and 3 may be novel markers of angiogenesis in psoriasis. PMID: 28238185
2. enhanced SCUBE1 concentrations are correlated with increasing severity and poor outcomes of aneurysmal subarachnoid hemorrhage patients, indicating SCUBE1 might have the potential to identify aneurysmal subarachnoid hemorrhage patients at risk of poor prognosis PMID: 27265525
3. Increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of intracerebral hemorrhage PMID: 27496080
4. SCUBE1 might be a novel prognostic biomarker after traumatic brain injury PMID: 26940951
5. describe novel mechanisms in targeting S1 to the plasma membrane and demonstrate that N-glycans are required for S1 functions during primitive haematopoiesis in zebrafish. PMID: 26699903
6. SCUBE1 may indicate hypercoagulability in patients with BC and thus help identify patients at greater risk of thrombosisSCUBE1 may indicate hypercoagulability in patients with breast cancer and thus help identify patients at greater risk of thrombosis PMID: 26438214
7. SCUBE1 levels are a new biomarker that can be used in the differential diagnosis and monitoring of patients hospitalized with suspected CCHF. PMID: 23632301
8. Primary prostatic cancer-associated fibroblasts (CAFs) were isolated and the expression of CAF markers, Dlk1 and SCUBE1 transcripts were characterised. PMID: 23136397
9. SCUBE 1 levels in patients with gastric cancer were found higher compared to healthy subjects. PMID: 23220851
10. SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event. PMID: 22874483
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亞細胞定位：

Secreted. Cell membrane; Peripheral membrane protein.
組織特異性：

Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the s
數據庫鏈接：

HGNC: 13441

OMIM: 611746

KEGG: hsa:80274

STRING: 9606.ENSP00000354080

UniGene: Hs.133995

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