SCGB2A1 Antibody

說明書

中文名稱：

SCGB2A1兔多克隆抗體
貨號：

CSB-PA993283
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA993283(SCGB2A1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA993283(SCGB2A1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O75556
基因名：

SCGB2A1
別名：

Lacryglobin antibody; LIPHC antibody; Lipophilin C antibody; Lipophilin-C antibody; LPHC antibody; LPNC antibody; Mammaglobin 2 antibody; Mammaglobin-2 antibody; Mammaglobin-B antibody; MGB2 antibody; MGC71973 antibody; Scgb2a1 antibody; Secretoglobin family 2A member 1 antibody; Secretoglobin; family 2A; member 1 antibody; SG2A1_HUMAN antibody; UGB3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human SCGB2A1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
基因功能參考文獻：
1. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
2. novel marker GATA3 stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples PMID: 25906123
3. The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome. PMID: 25425335
4. Results indicate that the quantitative analysis of h-MAM mRNA is a useful tool for detecting CTCs in breast cancer patients. PMID: 24706379
5. Results indicated that SCGB2A1 represented a novel, prognostic factor for colorectal cancer, and its expression correlated with chemoresistance, radioresistance and cancer cell stemness. PMID: 24585249
6. The data indicate that MGB1, MGB2 and LIPB mRNAs are expressed at low levels in human tissues but basal expression is upregulated in ovarian cancer. PMID: 24603286
7. SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers. PMID: 23807163
8. MGB has the highest expression in HER2-overexpressing breast cancers and may be a potentially useful marker for this subtype. PMID: 23332923
9. Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis. PMID: 20306663
10. The mammaglobin/lipophilin B complex is a promising diagnostic marker for breast cancer. PMID: 12022875
11. MGB2 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients. PMID: 15151203
12. SCGB 2A1 represents a new class of androgen target genes that are purely under indirect AR control mediated by DNA-bound Sp factors. PMID: 16020486
13. Results indicate that mammaglobin, as measured by the ELISA, holds significant promise for breast cancer screening with the realistic potential to impact management of this disease. PMID: 16166429
14. MGB-2 is highly expressed in endometrioid endometrial cancer [EEC], particularly in well- and moderately differentiated tumors, and may represent a novel molecular marker for EEC PMID: 18021217
15. Expression levels of mammaglobins A and B in nasal polyps are not different between patients with and without AR PMID: 18416968
16. MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome PMID: 19635143
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亞細胞定位：

Secreted.
蛋白家族：

Secretoglobin family, Lipophilin subfamily
組織特異性：

Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.
數據庫鏈接：

HGNC: 7051

OMIM: 604398

KEGG: hsa:4246

STRING: 9606.ENSP00000244930

UniGene: Hs.97644

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