SCG5 Antibody
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中文名稱：SCG5兔多克隆抗體
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貨號：CSB-PA020810GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：SCG5
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別名：SCG5 antibody; SGNE1Neuroendocrine protein 7B2 antibody; Pituitary polypeptide antibody; Secretogranin V antibody; Secretogranin-5 antibody; Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human SCG5
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
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基因功能參考文獻：
- Describe a hereditary mixed polyposis syndrome in which is characterized by SCG5-GREM1 duplication. PMID: 27984123
- FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
- 7B2 chaperones blocked the cytotoxic effects of exogenous hIAPP PMID: 24042052
- conclude that 7B2 is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers PMID: 22947085
- data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease PMID: 23172224
- the significant effects of SGNE1/7B2 on the growth and apoptosis of glioblastoma cells provide a first proof for a functional implication of SGNE1/7B2 inactivation in the molecular pathology of gliomas. PMID: 21901745
- SGNE1 was overexpressed in gastrointestinal peptide-independent ACTH-independent macronodular adrenal hyperplasia. hyperplasia PMID: 14767469
- SGNE1 identified as a novel epigenetically silenced gene in medulloblastomas and its inactivation, as well as its inhibitory effect on tumor cell proliferation and focus formation strongly argues for a significant role in medulloblastoma development. PMID: 17334394
- SGNE1 genetic variation does not contribute to obesity and common forms of Type 2 diabetes but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity PMID: 17617923
- Secretogranins V assays failed to detect increased concentrations in any of the patients with neuroendocrine tumours. PMID: 18448176
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亞細胞定位：Secreted. Note=Neuroendocrine and endocrine secretory granules.
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蛋白家族：7B2 family
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數據庫鏈接：
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