RXRG Antibody, Biotin conjugated

說明書

中文名稱：

RXRG兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA020614LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RXRG Polyclonal antibody
Uniprot No.：

P48443
基因名：

RXRG
別名：

MGC109416 antibody; NR2B3 antibody; Nuclear receptor subfamily 2 group B member 3 antibody; OTTHUMP00000060418 antibody; Retanoic X receptor gamma antibody; Retinoic acid receptor RXR gamma antibody; Retinoic acid receptor RXR-gamma antibody; Retinoid X receptor gamma antibody; RXR G antibody; RXR gamma antibody; RXRC antibody; Rxrg antibody; RXRG_HUMAN antibody; RXRgamma antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Retinoic acid receptor RXR-gamma protein (13-133AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.
基因功能參考文獻：
1. genetic association studies in a population in Brazil: Data suggest that SNPs in RXRG (rs2134095) and GC (rs7041) are associated with low-density lipoprotein cholesterol levels and hypercholesterolemia in the population studied; there was no apparent association with an SNP in VDR (rs2228570). (RXRG = retinoid X receptor gamma; GC = vitamin D-binding protein; VDR = vitamin D receptor) PMID: 27721113
2. Germline mutations in the RXRG gene are linked to Familial isolated pituitary adenoma in a Brazilian Family. PMID: 27245436
3. Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR. PMID: 26148973
4. loss of RXR-gamma levels appears to provide mechanistic benefits to transformed cells towards the acquisition of resistance to apoptosis hallmark of cancer PMID: 23936423
5. Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients. PMID: 23759678
6. The RXR-gamma rs3818569 single nucleotide polymorphisms is associated with diabetic retinopathy development in the Taiwanese population. PMID: 22180072
7. results indicate that RXR-gamma is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination. PMID: 21131950
8. methylation-associated downregulation of the RXRG gene may play a differential role in the carcinogenesis of non-small cell lung cancer (NSCLC) according to smoking status. PMID: 20113835
9. Single nucleotide polymorphism not a factor in resistance to thyroid hormone. PMID: 15186611
10. The retinoid X receptor, gamma expression is mainly restricted to the muscle and brain. PMID: 15608692
11. These results show that the stimulation of ASCT2 expression in response to glutamine in part involves binding of FXR/RXR to the ASCT2 promoter. PMID: 16197915
12. RXRgamma contributes to the genetic background of familial combined hyperlipidemia. PMID: 17272748
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Nuclear hormone receptor family, NR2 subfamily
組織特異性：

Expressed in aortic endothelial cells (at protein level).
數據庫鏈接：

HGNC: 10479

OMIM: 180247

KEGG: hsa:6258

STRING: 9606.ENSP00000352900

UniGene: Hs.26550

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