RXFP3 Antibody

說明書

中文名稱：

RXFP3兔多克隆抗體
貨號：

CSB-PA886335
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA886335(RXFP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA886335(RXFP3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA886335(RXFP3 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q9NSD7
基因名：

RXFP3
別名：

RXFP3; GPCR135; RLN3R1; SALPR; Relaxin-3 receptor 1; RLN3 receptor 1; G protein-coupled receptor SALPR; G-protein coupled receptor GPCR135; Relaxin family peptide receptor 3; Somatostatin- and angiotensin-like peptide receptor
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human RXFP3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
基因功能參考文獻：
1. This study indicated that RXFP3 mainly localised in the post-acrosomal region of sperm head and neck. PMID: 29159832
2. The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3. PMID: 27404393
3. Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research. PMID: 27498038
4. the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 PMID: 27353281
5. we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor PMID: 24641548
6. Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3. PMID: 24615237
7. demonstrate the existence of an allosteric site for modulation of RXFP3 PMID: 22347403
8. H3 relaxin potently activates all signaling pathways coupled to RXFP3, whereas H2 relaxin is an AP-1-biased ligand relative to H3 relaxin. PMID: 20159943
9. GPCR135 (SALPR) is the receptor for relaxin-3 PMID: 14522968
10. Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142. PMID: 15465925
11. functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins PMID: 15956730
12. analysis of truncated human relaxin-2 and -3 (H2 and H3) relaxin peptides and their binding and cAMP activities on RXFP1, RXFP2, and RXFP3 PMID: 18434306
13. the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation. PMID: 18582868
14. Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3. PMID: 19152634
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high leve
數據庫鏈接：

HGNC: 24883

OMIM: 609445

KEGG: hsa:51289

STRING: 9606.ENSP00000328708

UniGene: Hs.170146

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