RPS6KB2 Antibody

中文名稱：

RPS6KB2兔多克隆抗體
貨號：

CSB-PA02905A0Rb
規格：

￥440
圖片：
Western blot
All lanes: RPS6KB2 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 54, 17 kDa
Observed band size: 54 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02905A0Rb at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RPS6KB2 Polyclonal antibody
Uniprot No.：

Q9UBS0
基因名：

RPS6KB2
別名：

70 kDa ribosomal protein S6 kinase 2 antibody; EC 2.7.11.1 antibody; KS6B2_HUMAN antibody; p70 beta antibody; p70 ribosomal S6 kinase beta antibody; p70 S6 kinase beta antibody; p70 S6K-beta antibody; p70 S6KB antibody; p70 S6Kbeta antibody; p70(S6K) beta antibody; p70-beta antibody; p70-S6K 2 antibody; P70S6K2 antibody; p70S6Kb antibody; Ribosomal protein S6 kinase 70kDa; polypeptide 2 antibody; Ribosomal protein S6 kinase B2 antibody; Ribosomal protein S6 kinase beta 2 antibody; Ribosomal protein S6 kinase beta-2 antibody; Rps6kb2 antibody; S6 kinase related kinase antibody; S6 kinase-related kinase antibody; S6K beta 2 antibody; S6K beta antibody; S6K-beta antibody; S6K-beta-2 antibody; S6K2 antibody; Serine/threonine protein kinase 14 beta antibody; Serine/threonine-protein kinase 14B antibody; SRK antibody; STK14B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ribosomal protein S6 kinase beta-2 protein (1-210AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RPS6KB2 Antibody (CSB-PA02905A0Rb)，的標記方式是Non-conjugated。對于RPS6KB2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA02905B0Rb	RPS6KB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA02905C0Rb	RPS6KB2 Antibody, FITC conjugated
Biotin	CSB-PA02905D0Rb	RPS6KB2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.
基因功能參考文獻：
1. Overexpression of catalytically-active Akt or knockdown of glycogen synthase kinase-3 (GSK3)-beta, a substrate for Akt, had little effect on Mcl-1 downregulation caused by S6K2 deficiency PMID: 28301598
2. We propose that the S6K2/TRBP node controls miRNA biogenesis in HDLECs and provides a molecular link between the mTOR pathway and the miRNA biogenesis machinery. PMID: 27407113
3. discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in non-small-cell lung cancer PMID: 24469061
4. Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. PMID: 25124033
5. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer. PMID: 24131622
6. The p85 S6K1 promotes H2O2-induced cell death via a rapamycin-insensitive mechanism. PMID: 22955948
7. S6K2 amplification was frequently observed in gastric cancer and was related to a poor prognosis PMID: 23393338
8. Study shows that the two homologues of S6K have distinct effects on Akt activation and cell survivalin breast cancer. PMID: 21427355
9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
10. p70 S6 kinase regulates neutrophilic differentiation in HL-60 cells PMID: 12176053
11. regulation of nucleocytoplasmic shuttling of S6KbetaII by protein kinase C-mediated phosphorylation PMID: 12529391
12. the PI3K/p70 S6K/c-Myc cascade plays an important role in neutrophilic proliferation in HL-60 cells. PMID: 12818373
13. These data suggest that activated p70 S6 kinase could mediate an up-regulation of tau translation. PMID: 12875979
14. p70 ribosomal protein S6 kinase activity was induced by K-Ras in a phosphatidylinositol 3-kinase and mTOR-dependent manner. PMID: 14729629
15. S6K2 is active throughout the cell cycle with higher activity in G2 and M phases. PMID: 17786541
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
數據庫鏈接：

HGNC: 10437

OMIM: 608939

KEGG: hsa:6199

STRING: 9606.ENSP00000308413

UniGene: Hs.534345

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