RPA3 Antibody, HRP conjugated
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中文名稱：RPA3兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA16234B0Rb
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) RPA3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：p14 antibody; REPA 3 antibody; REPA3 antibody; Replication factor A protein 3 antibody; Replication protein A 14 kDa subunit antibody; Replication protein A3 14kD antibody; Replication protein A3 14kDa antibody; Replication protein A3 antibody; RF A antibody; RF A protein 3 antibody; RF-A protein 3 antibody; RFA protein 3 antibody; RFA3_HUMAN antibody; RP A antibody; RP A p14 antibody; RP-A p14 antibody; RPA 14 antibody; RPA 3 antibody; RPA p14 antibody; rpa3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Replication protein A 14 kDa subunit protein (1-119AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER), probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA. As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
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基因功能參考文獻：
- RPA3 is a potential marker of prognosis, radioresistance and survival in nasopharyngeal carcinoma. PMID: 28557284
- Elevated expression of RPA3 promotes tumor progression in hepatocellular carcinoma cells. PMID: 28683444
- Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival. PMID: 28766245
- The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma. PMID: 23573956
- RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA. PMID: 19010961
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亞細胞定位：Nucleus.
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數(shù)據(jù)庫鏈接：
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