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中文名稱：RNF43兔多克隆抗體
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貨號：CSB-PA019892LA01HU
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規格：￥440
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圖片：
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IHC image of CSB-PA019892LA01HU diluted at 1:600 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RNF43 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：RNF43 antibody; E3 ubiquitin-protein ligase RNF43 antibody; EC 2.3.2.27 antibody; RING finger protein 43 antibody; RING-type E3 ubiquitin transferase RNF43 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，RNF43 Antibody (CSB-PA019892LA01HU)，的標記方式是Non-conjugated。對于RNF43 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- LncRNA MIR503HG regulates NETs‐mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ X Ye, C Fang, W Hong, X Qian, B Yu,Clinical and Translational Medicine,2025
產品評價
相關產品
靶點詳情
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功能：E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
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基因功能參考文獻：
- results establish that RSPO2, without the LGR4/5/6 receptors, serves as a direct antagonistic ligand to RNF43 and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT-associated cancers PMID: 29769720
- Data suggest that inactivation of RNF43 and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype. PMID: 27661107
- Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
- RNF43 mutation constitutes an important mutated driver gene for the Serrated Neoplasia pathway in both the sporadic and familial Polyposis settings. PMID: 27329244
- RNF43 is down-regulated in intrahepatic cholangiocarcinoma and may play a crucial role during development of ICC. PMID: 26980022
- The finding of RNF43 mutation in sessile serrated adenoma and traditional serrated adenoma, but not in tubulovillous/villous adenoma, indicated that RNF43 mutation is an early and specific molecular aberration in the serrated colorectal carcinoma pathway. PMID: 27305845
- Mutations and downregulation of RNF43 may play a critical role in the transition from adenoma to carcinoma. PMID: 27514024
- PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs). PMID: 26924569
- our study exhibited the expression patterns and correlation of RNF43 and p53 pathway proteins involved in cell cycling PMID: 26823834
- Authors also identified ring finger 43 (RNF43), an inhibitor of Wnt/beta-catenin signaling, as a target of miR-550a-5p. PMID: 25961913
- RNF43 inhibits the Wnt pathway downstream of oncogenic mutations that activate the pathway. PMID: 26350900
- RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis PMID: 26184844
- RNF43 gene harbored not only exceedingly high mutations but also mutational intratumoral heterogeneity, which together might play a role in tumorigenesis of gastric and colorectal cancers. PMID: 26297255
- The nucleoprotein of influenza A virus targets RNF43 to modulate p53 ubiquitination levels and hence causes p53 stabilization which is conducive to an enhanced apoptosis level in the host cells. PMID: 25996295
- we found that the decreased expression of RNF43 in glioma was associated with poor prognosis by the Kaplan-Meier survival analysis. Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival. PMID: 25755738
- These results indicate that RNF43 mutation might cause downregulation of the expression of ring finger protein 43 and play a crucial role during development of intraductal papillary mucinous neoplasm of the pancreas. PMID: 25081753
- Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity. PMID: 25891077
- Missense mutations of RNF43 change their localization from the endosome to the endoplasmic reticulum. PMID: 25825523
- RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers PMID: 25344691
- Signalling potency of R-spondin proteins depends on their ability to recruit ZNRF3 or RNF43 via Fu1 into a complex with LGR receptors, which interact with Rspo via Fu2 PMID: 24225776
- RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer. PMID: 24001777
- mutational inactivation of RNF43 in pancreatic adenocarcinoma confers Wnt dependency PMID: 23847203
- RNF43 is involved in tumorigenesis and progression of human hepatocellular carcinoma. PMID: 23136185
- RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. PMID: 23096461
- RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation PMID: 22895187
- These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. PMID: 21108931
- RNF43 may exert its growth promoting effect in an antocrine manner and may be a novel diagnostic marker for colorectal cancer PMID: 15492824
- These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95. PMID: 18313049
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相關疾病：Sessile serrated polyposis cancer syndrome (SSPCS)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope.
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蛋白家族：ZNRF3 family
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組織特異性：Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
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