RNF212 Antibody
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中文名稱：RNF212兔多克隆抗體
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貨號：CSB-PA019872ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA019872ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RNF212 Polyclonal antibody
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Uniprot No.：
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基因名：RNF212
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別名：FLJ38841 antibody; Hypothetical protein LOC285498 antibody; LOC285498 antibody; OTTHUMP00000147525 antibody; Probable E3 SUMO-protein ligase RNF212 antibody; RING finger protein 212 antibody; RN212_HUMAN antibody; RNF 212 antibody; RNF212 antibody; ZHP3 antibody; ZHP3; C. elegans; homolog of antibody; ZIP3-related protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Probable E3 SUMO-protein ligase RNF212 protein (1-297AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.
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基因功能參考文獻：
- The polymorphism of SNP rs4045481 in RNF212 gene might be associated with azoospermia and genotype CC of this SNP may be a risk factor of azoospermia. PMID: 29277047
- This paper describes a partial transcript of the human RNF212 gene. PMID: 15340062
- genome search identified sequence variants in the 4p16.3 region correlated with recombination rate in males & females; variants are located in the RNF212 gene, a putative ortholog of ZHP-3 gene essential for recombination & chiasma formation in C elegans PMID: 18239089
- Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18239089
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亞細胞定位：Nucleus. Chromosome.
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數據庫鏈接：
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