RNF19A Antibody, Biotin conjugated
-
中文名稱：RNF19A兔多克隆抗體, Biotin偶聯(lián)
-
貨號：CSB-PA868327LD01HU
-
規(guī)格：￥880
-
其他：
產品詳情
-
產品名稱：Rabbit anti-Homo sapiens (Human) RNF19A Polyclonal antibody
-
Uniprot No.：
-
基因名：RNF19A
-
別名：AA032313 antibody; DKFZP566B1346 antibody; Dorfin antibody; Double ring finger protein antibody; Double ring-finger protein antibody; E3 ubiquitin-protein ligase RNF19A antibody; p38 antibody; p38 protein antibody; Ring finger protein 19 antibody; RING finger protein 19A antibody; Ring IBR ring domain containing protein Dorfin antibody; RN19A_HUMAN antibody; RNF19 antibody; RNF19A antibody; Ubce7ip2 antibody; UIP117 antibody; XYbp antibody
-
宿主：Rabbit
-
反應種屬：Human
-
免疫原：Recombinant Human E3 ubiquitin-protein ligase RNF19A protein (741-825AA)
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Biotin
-
克隆類型：Polyclonal
-
抗體亞型：IgG
-
純化方式：>95%, Protein G purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
-
應用范圍：ELISA
-
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
-
基因功能參考文獻：
- A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
- Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
- results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
- These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
- Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
- Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
- Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867
顯示更多
收起更多
-
亞細胞定位：Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
-
蛋白家族：RBR family, RNF19 subfamily
-
組織特異性：Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
