RNASE3 Antibody
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中文名稱：RNASE3兔多克隆抗體
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貨號：CSB-PA367981
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA367981(RNASE3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA367981(RNASE3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: U937 cells, Primary antibody: CSB-PA367981(RNASE3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：RNASE3
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別名：Cytotoxic ribonuclease antibody; ECP antibody; ECP_HUMAN antibody; Eosinophil cationic protein antibody; OTTHUMP00000164017 antibody; Ribonuclease 3 antibody; Ribonuclease; RNase A family; 3 antibody; RNase 3 antibody; RNASE3 antibody; RNS3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human RNASE3
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
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基因功能參考文獻：
- measuring serum ECP levels is helpful for assessing the efficacy of inhaled corticosteroids therapy in bronchial asthma children. PMID: 28781336
- Data suggest that radioactive I(131) therapy leads to down-regulation of secretion of ECP from Th2 cells (helper-inducer T-lymphocytes) in post-thyroidectomy patients treated for differentiated thyroid cancer; in this study, ECP levels in serum were analyzed before, 3 days after, and 7 days after radiotherapy with I(131). PMID: 29066479
- our data add new insights into the pathophysiology of AD, suggesting that BDNF which correlates with disease severity and ECP levels contributes to the regulation of inflammation in an eosinophil-, but not Th2-dependent manner. PMID: 27087278
- High circulating levels of eosinophil cationic protein are associated with increased incidence of ischemic stroke. PMID: 28904229
- Studies mapped the structural determinants required for the eosinophil cationic protein (ECP)-bacterial lipopolysaccharide (LPS) interaction by nuclear magnetic resonance. PMID: 27696685
- Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD. PMID: 27022611
- Children in the acute-phase group showed higher ECP mRNA expression level than those in the stable-phase and healthy control groups, while the level in the stable-phase was markedly higher than that in the healthy control group. PMID: 26600485
- drug eluting stent polymers increase eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein PMID: 25463127
- Around half of all variance in serum ECP is explained by genetic factors. Serum ECP is influenced by sex, BMI, and airway responsiveness. Serum ECP and airway responsiveness seem not to share genetic variance. PMID: 25354326
- eosinophil cationic protein levels can be used to diagnosis atopic dermatitis but cannot distinguish between intrinsic and extrinsic disease. PMID: 24129707
- The antimicrobial protein, Rnase 3, contributes to the host immune response against mycobacteria. PMID: 23716047
- ECP was elevated in nasal discharge of patients with nasal polyps compared to controls and those with allergic rhinitis or rhinosinusitis. PMID: 23430080
- report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (EPX/EDN, RNase2) and the association with the cellular contents of EPX/EDN and ECP PMID: 24738159
- Eosinophil cationic protein is not cytotoxic but enhances the growth of normal human dermal fibroblasts PMID: 24383969
- Effects of omalizumab on eosinophil cationic peptide, 25-hydroxyvitamin-D, IL-1beta and sCD200 in cases of Samter's syndrome PMID: 23841472
- Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, alpha2M and CP as well as CysLT may be involved in eosinophilic inflammation. PMID: 23786280
- Eosinophil cationic protein is a major granule-derived protein with cytotoxic activity found in eosinophils and has been known as a useful marker of allergic inflammation. PMID: 23710948
- Polymorphisms of EPX and ECP are associated to inflammatory bowel disease in an age and gender dependent manne. PMID: 23197886
- novel insights to identify functional regions of hRNase3 that may have implications for all hRNaseA superfamily members. PMID: 23484086
- This study also suggests that eosinophils and eosinophil cationic protein take part in the pathogenesis of nonallergic rhinitis. PMID: 23406588
- Lower ECP levels in the active phase of the disease may be a result of decreased production due to the activation of Th1 cytokines. PMID: 23517396
- A fraction of native ECP is stored in a non-cytotoxic form, which can be converted into a cytotoxic form by N-deglycosylation, whereas another fraction is stored as a highly cytotoxic form carrying different post-translational modifications PMID: 23597768
- Eosinophil cationic protein might induce mesoderm differentiation through fibroblast growth factor signaling pathway and enhance subsequent cardiomyocyte differentiation in concert with dimethyl sulfoxide in P19CL6 cells. PMID: 22845717
- a marker of asthma severity within an asthmatic paediatric population PMID: 21962901
- Results reveal the structural basis for the high affinity of ECP for glycosaminoglycans. PMID: 22579681
- biological and genetic characteristics of ECP PMID: 22845733
- 371G allele of RNASE3 is associated with susceptibility to cerebral malaria and forms part of a risk associated haplotype GGA defined by the markers PMID: 22216286
- Total serum IgE, ECP and eosinophil percentage are strong predictors of allergic rhinitis. PMID: 22289536
- The data suggests presence of relationship between development of restenosis and elevated blood plasma Eosinophilic cation protein level in patients with IHD after revascularization. PMID: 21878071
- ECP heparin binding affinity depends on its RNase catalytic site PMID: 20213669
- basal ECP levels are associated with major advemse cardiac evemts after bare metal stent implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting. PMID: 21183182
- Arg22, Arg34, Arg61, Arg77 and His64 of ECP are crucial for eosinophil cationic proteins's membrane destabilization activity, which appears to be the underlying mechanism of its cytotoxic, antibacterial and antiparasitic activities. PMID: 21303303
- The expression level of ECP mRNA was up-regulated in nasal polyps. PMID: 19086659
- the shortest ECP minimized version that would retain its antimicrobial properties PMID: 20951760
- ECP is present in the middle ear effusion of otitis media of effusion. There was a positive correlation between ECP level and IgE level. PMID: 16883790
- Among mite-allergic patients T-bet expression was down-regulated, which had no relation to ECP concentration and allergic symptoms. PMID: 16874959
- elevated levels in nasal lavage in allergic asthmatics PMID: 21038779
- Eosinophil cationic protein may have a role in coronary atherosclerosis PMID: 20307883
- There are associations of symptoms of allergy and asthma to ECP-genotypes, but also to smoking habits. ECP may be involved in impairment of lung functions in disease. PMID: 20534163
- Serum levels of ECP, IL-5, -6, -8 and -10, G-CSF, MCP-1, IL-1 ra and IP-10 were significantly elevated in acute compared with stable childhhood asthma. PMID: 20523065
- Results showed that OSCC patients with intense TATE and at least one C allele had a higher frequency of bilateral neck dissection, local recurrence, vascular embolization, involved resection margins, and postoperative radiotherapy. PMID: 19566743
- Our study suggests that RNase3 polymorphisms are potentially associated with susceptibility to allergic rhinitis. PMID: 19760211
- The eosinophil cationic protein increased TNF-alpha production in BEAS-2B cells and triggered apoptosis by caspase-8 activation through mitochondria-independent pathway. PMID: 20089176
- The mean of serum ECP was significantly higher in patients with respiratory tract diseases (asthma, COPD, interstitial lung disease, and respiratory infections) compared with healthy volunteers. PMID: 20170318
- Data show that conformational diversity of ECP is observed for the loop segments 17-22, 65-68, and 92-95 and most exposed sidechains. PMID: 19189375
- Measurement of ECP polymorphism is a significant indicator for the disease activity in asthmatic patient. PMID: 12524255
- serum levels elevated in asthmatic patients during acute attack PMID: 12530121
- results suggest a differential release of ECP by the serum eosinophil, depending on the disease status and asthma exacerbation severity PMID: 12974194
- Presence of ECP in human milk is associated with development of cow milk allergy and atopic dermatitis in the breast-fed infant, but has no direct association with the maternal atopy. PMID: 14630983
- ECP contributes to surfactant dysfunction in asthma, which in turn could lead to airway obstruction. PMID: 15007353
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亞細胞定位：Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
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蛋白家族：Pancreatic ribonuclease family
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