RMI1 Antibody

中文名稱：

RMI1兔多克隆抗體
貨號：

CSB-PA875699LA01HU
規格：

￥440
圖片：
Western blot
All lanes: RMI1 antibody at 4μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RMI1 Polyclonal antibody
Uniprot No.：

Q9H9A7
基因名：

RMI1
別名：

BLAP75 antibody; BLM associated polypeptide 75 kDa antibody; BLM associated protein 75 kDa antibody; BLM-associated protein of 75 kDa antibody; C9orf76 antibody; FAAP75 antibody; FLJ12888 antibody; Homolog of yeast RecQ mediated genome instability 1 antibody; RecQ mediated genome instability 1 antibody; RecQ-mediated genome instability protein 1 antibody; Rmi1 antibody; RMI1 homolog antibody; RMI1 RecQ mediated genome instability 1 homolog antibody; RMI1_HUMAN antibody; RP11-346I8 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human RecQ-mediated genome instability protein 1 protein (181-443AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RMI1 Antibody (CSB-PA875699LA01HU)，的標記方式是Non-conjugated。對于RMI1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA875699LB01HU	RMI1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875699LC01HU	RMI1 Antibody, FITC conjugated
Biotin	CSB-PA875699LD01HU	RMI1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
基因功能參考文獻：
1. RMI1 knockdown cells exhibit accumulation of broken DNAs after being released from hydroxyurea treatment. Moreover, we demonstrate that RMI1 facilitates the recovery from activated checkpoint and resuming the cell cycle after replicative stress. PMID: 29042194
2. RMI1 protein level does not change through G1, S and G2 phases, but significantly increases in M phase. PMID: 26556339
3. a model that maps all functionally important structural features for yeast Rmi1 and structure-prediction-based alignment with the recently established crystal structure of the N-terminus of human Rmi1, is proposed. PMID: 26717309
4. The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex. PMID: 25200081
5. two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner. PMID: 24108125
6. RMI1 is required to promote normal replication fork progression PMID: 22645306
7. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex PMID: 20826342
8. human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity PMID: 20445207
9. No evidence was found for an association between RMI1 S455N (rs1982151) and colorectal cancer risk. PMID: 19945966
10. BLAP75/RMI1 acts by recruiting TOPO IIIalpha to double Holliday junctions PMID: 16537486
11. BLM, Topo IIIalpha, and BLAP75 constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation PMID: 16595695
12. BLM is stably associated with RMI1 protein. PMID: 17728255
13. Genetic variant of the human homologous recombination-associated gene RMI1 is associated with acute myeloid leukemia, myelodysplatic syndromes and malignant melanoma PMID: 17900800
14. evolutionarily conserved N-terminal third of BLAP75 mediates complex formation with BLM and Topo IIIalpha and that the DNA binding activity resides in the C-terminal third of this novel protein. PMID: 18390547
15. Individuals carrying genetic variants of the BLM-TOP3A-RMI1 complex have an increased risk of acute myeloid leukemia/myelodysplatic syndromes, malignant melanoma, bladder and breast cancer. PMID: 19432957
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亞細胞定位：

Nucleus. Note=Forms foci in response to DNA damage.
蛋白家族：

RMI1 family
數據庫鏈接：

HGNC: 25764

OMIM: 610404

KEGG: hsa:80010

STRING: 9606.ENSP00000317039

UniGene: Hs.726327

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