RLIM Antibody
-
中文名稱：RLIM兔多克隆抗體
-
貨號：CSB-PA019748GA01HU
-
規格：￥3,900
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：RLIM
-
別名：E3 ubiquitin-protein ligase RLIM antibody; LIM domain-interacting RING finger protein antibody; R-LIM antibody; Renal carcinoma antigen NY-REN-43 antibody; RING finger LIM domain-binding protein antibody; RING finger protein 12 antibody; RLIM antibody; RNF12 antibody; RNF12_HUMAN antibody
-
宿主：Rabbit
-
反應種屬：Human,Mouse,Rat
-
免疫原：Human RLIM
-
免疫原種屬：Homo sapiens (Human)
-
抗體亞型：IgG
-
純化方式：Antigen Affinity purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
產品提供形式：Liquid
-
應用范圍：ELISA,WB
-
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
-
基因功能參考文獻：
- Results from a study on gene expression variability markers in early-stage human embryos shows that RLIM is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
- missense mutation in RLIM gene was identified in four males with intellectual disability from a three-generation family. PMID: 25735484
- RNF12 is a novel positive regulator of p53 pathway and an external E3 ubiquitin ligase for MDM2 destruction. PMID: 26926424
- Rlim is a novel regulator of Stathmin protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin protein in human osteosarcomas. PMID: 24686088
- hus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival PMID: 23904271
- TP53 does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 to the RLIM promoter. PMID: 23650532
- these results indicated that RLIM is an important positive regulator in TGF-beta signaling pathway and cell migration. PMID: 21945933
- RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 at telomeres. PMID: 19164295
- These findings provide evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process. PMID: 19945382
- Functional analysis of the Xenopus homolog PMID: 12874135
顯示更多
收起更多
-
相關疾病：Mental retardation, X-linked 61 (MRX61)
-
亞細胞定位：Nucleus.
-
蛋白家族：RNF12 family
-
組織特異性：Expressed in many tissues.
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
