RIOK3 Antibody
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中文名稱：RIOK3兔多克隆抗體
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貨號：CSB-PA070146
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：RIOK3
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別名：Homolog of the Aspergillus nidulans sudD gene product antibody; RIO kinase 3 (yeast) antibody; RIO kinase 3 antibody; RIOK3 antibody; RIOK3_HUMAN antibody; Serine/threonine protein kinase RIO3 antibody; Serine/threonine-protein kinase RIO3 antibody; SudD (suppressor of bimD6; Aspergillus nidulans) homolog antibody; SUDD antibody; sudD homolog antibody; SudD suppressor of Aspergillus nidulans bimD6 homolog antibody; SudD suppressor of bimD6 homolog antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human SUDD.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.
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基因功能參考文獻：
- RIO kinase 3 (RIOK3) positively regulates the activity of the AKT/mTOR pathway in glioma cells. PMID: 29233656
- the ectopic expression of RIOK3 or a phosphomimetic MDA5-S828D mutation attenuated MDA5-mediated signaling. PMID: 25865883
- These findings demonstrate that RIOK3 is necessary for maintaining actin cytoskeletal organisation required for migration and invasion, biological processes that are necessary for hypoxia-driven metastasis. PMID: 25486436
- Functionally, RIOK3 acts as a SUFU-dependent positive regulator of Hedgehog signaling. PMID: 24018050
- Authors found that RIOK3 physically interacts with TBK1 and IRF3 and bridges the functions between TBK1 and IRF3 in the activation of type I interferon pathway. PMID: 24807708
- RioK3 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA. PMID: 22418843
- Like RIOK3, PAK4 promotes pancreas ductal cell motility and invasion in pancreatic cancer PMID: 19050074
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亞細胞定位：Cytoplasm.
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蛋白家族：Protein kinase superfamily, RIO-type Ser/Thr kinase family
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組織特異性：Widely expressed.
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數據庫鏈接：
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