RHOC Antibody

說明書

中文名稱：

RHOC兔多克隆抗體
貨號：

CSB-PA019687GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P08134
基因名：

RHOC
別名：

Aplysia RAS-related homolog 9 antibody; ARH 9 antibody; ARH9 antibody; ARHC antibody; H9 antibody; MGC1448 antibody; MGC61427 antibody; Oncogene RHO H9 antibody; Ras homolog gene family member C antibody; RAS related homolog 9 antibody; RHO C antibody; Rho cDNA clone 9 antibody; Rho related GTP binding protein RhoC antibody; Rho-related GTP-binding protein RhoC antibody; rhoC antibody; RhoC GTPase antibody; RHOC_HUMAN antibody; RHOH 9 antibody; RHOH9 antibody; Small GTP binding protein RhoC antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human RHOC
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
基因功能參考文獻：
1. LncRNA TDRG1 overexpression induced tumor development and RhoC expression. PMID: 28984384
2. Studied the involvement in epithelial ovarian cancer (EOC) of lncRNA ABHD11-AS1 in and the regulation of EOC by RhoC. PMID: 28818073
3. YMO1 suppresses tumor invasion and metastasis by inhibiting RhoC activity. PMID: 27487132
4. this studies show the ability of miR-10b to activate the expression of c-Jun through RhoC and NF1, which represents a novel pathway for promoting migration and invasion of human cancer cells PMID: 27494896
5. swapping residue 188 identity effectively flips the membrane binding profile of wild-type RhoA and RhoC through positive arginine contribution rather than negative phosphoserine regulation PMID: 27355867
6. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells. PMID: 28069441
7. E2F transcription factor 1 (E2F1) downregulated micrRNA miR-519d directly and miR-519d downregulated Ras homolog gene family member C (RhoC) directly. PMID: 28146423
8. During the process of epithelial-mesenchymal transition in A549 cells induced by TGF-beta1, upregulated RhoC protein and RhoC activity were detected, which was associated with the enhanced invasive capability of the cells in vitro. PMID: 27748883
9. RhoC downregulation may inhibit the proliferation, drug resistance, invasion and migration of ovarian cancer stem cells. PMID: 27748937
10. Downregulation of RHOC inhibited cholangiocellular carcinoma cells invasion and migration partially via inhibition of matrix metalloproteinase 2, 3 and 9 expression. RHOC also modulated the expression of several epithelial-mesenchymal transition (EMT)-associated proteins PMID: 27108649
11. RT-PCR and Western blot assays demonstrated that miR-372 transfection reduced the expression of RhoC. PMID: 26673619
12. study has identified several new proteins like RHOC, DLG5, UGDH, TMOD3 in addition to known chemoresistance associated proteins in non-small cell lung carcinoma. PMID: 26898345
13. the oncogene RhoC, a driver of metastatic potential, modulates glutamine and N-acetylaspartate metabolism in Inflammatory Breast Cancer cells in vitro, revealing a novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well known role in cytoskeletal rearrangement. PMID: 27129239
14. The knockdown of RhoC protein decreased the proliferation rate of the parental and the IE1-expressing glioblastoma cells. PMID: 26741994
15. found that miR-10b induced HCC cell invasion and migration by modulating the HOXD10 target gene RhoC, uPAR, MMP-2 and MMP-9 expression PMID: 25236186
16. Smart particles encapsulating the scrambled siRNA sequence did not affect RhoC protein expression. PMID: 26020100
17. Depletion of the kinases ROCK1 and ROCK2, two known RhoC downstream effectors, similarly decreases cancer interaction with ECs PMID: 25677806
18. Results identify RhoC as a prominent binding partner of RhoGDI2 and show that RhoGDI2 modulates RhoC activity in cells promoting lung colonization of bladder cancer cells. PMID: 25516960
19. Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway. PMID: 25933027
20. MiR-93-5P may inhibit EOC tumorigenesis and progression by targeting RhoC. PMID: 25649143
21. miR-509 has a critical role in brain metastasis of breast cancer by modulating the RhoC-TNF-alpha network. PMID: 25659578
22. RhoC protein may upregulate VEGF expression, thereby promoting tumor angiogenesis in esophageal squamous cell carcinoma. PMID: 25624724
23. This is the first report in HNSCC demonstrating the role RhoC plays in mediating EGF-stimulated migration and invasion by down-regulating the PI3K-Akt pathway and E-cadherin expression. PMID: 25622907
24. may contribute to an epithelial-mesenchymal transition and drug resistance in human breast cancer during chemotherapy PMID: 25123151
25. RhoC expression might be involved in epithelial-to-mesenchymal transition of ovarian epithelial carcinoma cells. PMID: 24986540
26. Down-regulation of RhoC expression resulted in decreased migration of neural stem cells. PMID: 24414340
27. RhoC has a role in regulating cancer stem cells in head and neck squamous cell carcinoma through the over expression of IL-6 and phosphorylation of STAT3 PMID: 24533098
28. The S1P2R specifically activates RhoC via G12/13 proteins and LARG. PMID: 23993968
29. RhoC/ROCK1 signaling pathways are likely involved in the progression of cervical squamous cell carcinoma PMID: 24457551
30. RhoC facilitates tumor cell invasion and promotes subsequent metastasis, in part, by enhancing integrin alpha5beta1 trafficking PMID: 24312560
31. The up-regulated RhoC expression may affect ovarian carcinogenesis and should be considered a good biomarker for the differentiation and progression of ovarian carcinoma PMID: 23764197
32. Increased RHOC expression was detected in endometriotic lesions compared to the eutopic endometrium of women with endometriosis and control women. PMID: 23302395
33. HBx and HBs of hepatitis B virus could increase expression of Ets-1, which consequently contributed to the upregulation of RhoC. PMID: 23474984
34. This study demonstrated the role of RhoC overexpression in malignant transformation of normal human hepatocytes, suggesting that RhoC may function as an oncogene in hepatocytes. PMID: 23382905
35. data suggest that RhoC is a key regulator of cell growth and apoptosis in human hepatocellular carcinoma cells PMID: 21674277
36. RhoC stimulates the proliferation of gastric cancer cells through recruiting IQGAP1 as an effector. PMID: 23145020
37. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 PMID: 23319595
38. Increased prostate RhoC expression predicted a good outcome after radical prostatectomy for high-grade prostate cancer. PMID: 22935975
39. RhoC impacts the metastatic potential and abundance of breast cancer stem cells. PMID: 22911725
40. Substitution of RhoC Ile 43 with a Val increased guanine nucleotide exchange factors-catalyzed exchange in vitro. PMID: 22673745
41. Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
42. Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers. PMID: 22217540
43. Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors. PMID: 22293682
44. miR-493 is a new tumor suppressor miRNA in bladder cancer and inhibits cell motility through downregulation of RhoC and FZD4. PMID: 22057916
45. In a signaling cascade, the loss of E-cadherin activates the transcriptional regulator ETS-1 and consequently leads to the induction of RhoC expression that stabilizes c-Jun in melanoma. PMID: 21732343
46. Expression levels of RhoC and ROCK-1 in prostate carcinoma are higher than those in corresponding paracancerous tissues, showing a significant positive correlation with distant metastasis. PMID: 21575520
47. p38gamma mitogen-activated protein kinase regulates breast cancer cell motility and metastasis, in part, by controlling expression of the metastasis-associated small GTPase RhoC. PMID: 21862636
48. RHOC expression was induced by direct p53 binding to a regulatory element within the RHOC gene. PMID: 21079653
49. The knockdown of RhoC expression had no effect on the migration-stimulatory activity of IQGAP1. PMID: 21537845
50. RhoC promotes polarized tumor cell migration through FMNL3 by restricting lamellipodial broadening. PMID: 21576392
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亞細胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
蛋白家族：

Small GTPase superfamily, Rho family
數據庫鏈接：

HGNC: 669

OMIM: 165380

KEGG: hsa:389

STRING: 9606.ENSP00000285735

UniGene: Hs.502659

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