RGS6 Antibody

中文名稱：

RGS6兔多克隆抗體
貨號：

CSB-PA019658LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat heart tissue
All lanes: RGS6 antibody at 8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55, 57, 54, 50, 51, 53, 52, 41, 56 kDa
Observed band size: 55 kDa

IHC image of CSB-PA019658LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA019658LA01HU diluted at 1:300 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA019658LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RGS6 Polyclonal antibody
Uniprot No.：

P49758
基因名：

RGS6
別名：

FLJ43552 antibody; G protein signaling 6 regulator antibody; GAP antibody; GTPase activating protein antibody; MGC142132 antibody; Regulator of G protein signaling 6 antibody; Regulator of G protein signalling 6 antibody; Regulator of G-protein signaling 6 antibody; RGS 6 antibody; RGS6 antibody; RGS6_HUMAN antibody; S914 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Regulator of G-protein signaling 6 protein (177-262AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RGS6 Antibody (CSB-PA019658LA01HU)，的標記方式是Non-conjugated。對于RGS6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA019658LB01HU	RGS6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019658LC01HU	RGS6 Antibody, FITC conjugated
Biotin	CSB-PA019658LD01HU	RGS6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.
基因功能參考文獻：
1. the results suggest that HA117 regulates the development of drug resistance in CT26 cells in vitro and in vivo. PMID: 28731026
2. study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 and by down-regulating the expression of the GGL domain of RGS6 PMID: 28665981
3. genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied. PMID: 28090039
4. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS6 in fine-tuning TRPC4 activities. PMID: 26987813
5. Our results suggest that HA117 is a strong multidrug resistance gene. PMID: 20635168
6. This suggests that HA117 might be an important resistance gene in pediatric solid tumors. PMID: 23619123
7. No significant association between SNPs of RGS6 and central adiposity has been found. PMID: 26340433
8. reduced RGS6 expression is associated with poor survival in colorectal cancer patients, suggesting that RGS6 expression may serve as an important prognostic marker PMID: 26653562
9. these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target. PMID: 25120791
10. we found a novel mutation in RGS6, the splice-acceptor variant c.1369-1G>C that was not previously reported in congenital cataract phenotypes. PMID: 25525169
11. genetic association studies in Hispanic-American families in Texas and Colorado: SNP in RGS6 are associated with high dietary fat intake, food preferences, and adiposity/obesity phenotype PMID: 21233807
12. RGS6-induced apoptosis in both breast cancer cells and mouse embryonic fibroblasts does not require its GAP activity toward G proteins PMID: 21041304
13. interacts with SCG10 and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of this protein PMID: 12140291
14. Role of the RGS domain in stress-induced trafficking of RGS6 protein PMID: 12761220
15. RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants PMID: 12761221
16. RGS6 is the first member of the RGS protein family shown to interact with proteins involved in transcriptional regulation. PMID: 14734556
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亞細胞定位：

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cell membrane.
數據庫鏈接：

HGNC: 10002

OMIM: 603894

KEGG: hsa:9628

STRING: 9606.ENSP00000451030

UniGene: Hs.509872

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