RGS4 Antibody, HRP conjugated

說明書

中文名稱：

RGS4兔多克隆抗體, HRP偶聯
貨號：

CSB-PA019656LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RGS4 Polyclonal antibody
Uniprot No.：

P49798
基因名：

RGS4
別名：

MGC2124 antibody; MGC60244 antibody; Regulator of G protein signalling 4 antibody; Regulator of G-protein signaling 4 antibody; RGP 4 antibody; RGP4 antibody; RGS 4 antibody; RGS4 antibody; RGS4_HUMAN antibody; Schizophrenia disorder 9 antibody; SCZD 9 antibody; SCZD9 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Regulator of G-protein signaling 4 protein (1-205AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
基因功能參考文獻：
1. Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
2. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS4 in fine-tuning TRPC4 activities. PMID: 26987813
3. The results of this study demonstrated the association between the variation in the regulator of G-protein signaling 4 (RGS4) gene, a putative candidate gene for psychosis previously associated with schizophrenia endophenotypes, and psychotic-like experiences (PLEs). PMID: 26910404
4. All of these results confirmed the critical role of RGS4 in NSCLC progression. PMID: 26640232
5. After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR PMID: 26119705
6. RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events. PMID: 26088132
7. RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling. PMID: 25289860
8. RGS4 and COMT risk variants are associated with brain structural alterations in patient with schizophrenia. PMID: 23911251
9. genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA. PMID: 23332465
10. The results suggest unaltered membrane RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression. PMID: 23093381
11. dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants PMID: 23630294
12. Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia. PMID: 22157635
13. Cys-2 and Cys-12 play markedly different roles in the regulation of RGS4 membrane localization, intracellular trafficking, and G(q) inhibitory function via mechanisms that are unrelated to RGS4 protein stabilization. PMID: 22753418
14. RGS4 gene variations specifically disrupt prefrontal control of saccadic eye movements. PMID: 21910931
15. These studies indicate that increased RGS4 expression promotes a phenotypic switch of airway smooth muscle, evoking irreversible airway obstruction in subjects with severe asthma. PMID: 22253691
16. The researchers found evidence that there were significant differences between the D1S1656 locus in the Maghreb population and other populations. PMID: 21674833
17. RGS4 and RGS10 proteins are detected in postmortem prefrontal cortex. PMID: 20816714
18. Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk. PMID: 21209077
19. RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample. PMID: 19282471
20. Localization of Sst2 to the projection prevents excess G-protein activation during the pheromone response. PMID: 20712983
21. RGS4 is a potential susceptible gene for bipolar disorder. PMID: 20414142
22. A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. PMID: 20630860
23. A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A. PMID: 19937977
24. cytosolic and membrane levels of RGS4 may contribute to the regional differences in the coupling of muscarinic M1 receptors in Alzheimer's disease PMID: 12422374
25. A significant decrease in the transcript encoding regulator of G-protein signaling 4 (RGS4) in the prefrontal cortex of patients with schizophrenia. PMID: 12436019
26. results suggest that palmitoylation of a Cys residue in the regulator of G protein signaling(RGS) box is critical for RGS16 and RGS4 GAPase activating protein activity and their ability to regulate G protein signaling in mammalian cells PMID: 12642592
27. The data of this research give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia. PMID: 14732600
28. RGS4 mRNA distribution in human postmortem tissue from normal persons was very dense in most cortical layers examined, with lower density in the basal ganglia and thalamus. PMID: 15182322
29. Results could be interpreted as supporting evidence for the association between RGS4 and schizophrenia. PMID: 15274033
30. RGS4 and beta-tubulin modulate Galpha-GDP and Galpha-GTP states thus modulating MT1 melatonin receptor function. PMID: 15369705
31. RGS4 polymorphisms are associated with alterations in dorsolateral prefrontal cortex (area 9) volumes among schizophrenic patients. PMID: 15381923
32. Although gross indices of signaling were unaffected by RGS4, it slowed the rate of increase in Ins(1,4,5)P3 levels. PMID: 15383626
33. In schizophrenia, significant case-control differences were not observed, though the TDT suggested transmission distortion. For bipolar disorder, an omnibus test suggested differences in the overall distribution of haplotypes bearing all four SNPs. PMID: 15660667
34. No association is identified between RGS4 single nucleotide polymorphism (SNP) markers, genotypes, or haplotypes and schizophrenia PMID: 16082709
35. Data do not directly replicate previous associations of RGS4, but association with SNP 7 in the Scottish population provides some support for a role in schizophrenia susceptibility. PMID: 16176390
36. These results provide the first demonstration of a Ca(2+)-dependent interaction between RGS4 and CaM in vivo and show that association in lipid rafts of the plasma membrane might be involved in this physiological regulation of RGS proteins. PMID: 16246308
37. Finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility. PMID: 16508931
38. Results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated with three SNP markers from promoter region and intron 1. PMID: 16526029
39. RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia. PMID: 16860780
40. Genetic polymorphisms within RGS4 are unlikely to confer an increased susceptibility to the etiology of schizophrenia. PMID: 16904822
41. RGS4 mRNA was inversely correlated with COMT enzyme activity in the dorsolateral prefrontal cortex PMID: 16905560
42. SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT. PMID: 17006672
43. RGS4 single nucleotide polymorphism impacts frontal lobe blood oxygenation level-dependent response and network coupling during working memory and results in reductions in gray, white matter structural volume in individuals carrying the A allele. PMID: 17301167
44. In RGS4, the G-allele of the previously reported SNP RGS4-1 (single and as part of haplotypes with SNP RGS4-18) was associated with non-deficit schizophrenia but not with deficit schizophrenia. PMID: 17410640
45. study identified all common RGS4 polymorphisms & evaluated patterns of linkage disequilibrium in relation to schizophrenia; 2 haplotypes reported to confer liability to SZ had significant promoter activity suggesting functional role for both haplotypes PMID: 17515439
46. RGS4 genotypes predicted both the severity of baseline symptoms and relative responsiveness to antipsychotic treatment in patient with schizophrenia. PMID: 17588543
47. Full length cloning and expression analysis of splice variants of RGS4 were performed. PMID: 17707117
48. the association of regulator of G-protein signalling 4 protein polymorphisms with the phenotypic subgroups of schizophrenia. PMID: 17722013
49. The isolation and characterization of a novel human RGS4 mutant which displays enhanced or gain-of-function (GOF) activity, is described. PMID: 18031991
50. RGS4 variances influence clinical manifestations of schizophrenia PMID: 18204343
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相關疾病：

Schizophrenia (SCZD)
組織特異性：

Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.
數據庫鏈接：

HGNC: 10000

OMIM: 181500

KEGG: hsa:5999

STRING: 9606.ENSP00000397181

UniGene: Hs.386726

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