RGN Antibody
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中文名稱：RGN兔多克隆抗體
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貨號：CSB-PA019630GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：RGN
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別名：Gluconolactonase antibody; GNL antibody; RC antibody; Regucalcin antibody; RGN antibody; RGN_HUMAN antibody; Senescence marker protein 30 antibody; SMP 30 antibody; SMP-30 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human RGN,SMP30
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities.
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基因功能參考文獻：
- Study suggests that regucalcin plays a crucial role as a suppressor in human colorectal cancer, and that the suppressed expression of the regucalcin gene may predispose patients to the promotion of colorectal cancer. PMID: 29956741
- The SMP30 may serve as a candidate of HCC clinical prognostic marker. PMID: 27991558
- Dat show that regucalcin (RGN) is lowly expressed in hepatocellular carcinoma (HCC) tissues and down-regulates the proliferation ability of HepG2 cells. PMID: 28028056
- These findings suggest that regucalcin may play a potential role as a suppressor of human lung cancer, and that downregulation of regucalcin expression may predispose patients to development of lung cancer. PMID: 28181135
- The role of RGN suppressing cell proliferation is associated with the regulation of expression of oncogenes and tumor suppressor genes. [review] PMID: 27411833
- High RGN expression is associated with hepatocellular carcinoma. PMID: 27633001
- the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome. PMID: 27221776
- Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways. PMID: 26935290
- Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis. PMID: 26619319
- data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells. PMID: 25847529
- immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients PMID: 26072307
- results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa. PMID: 26171977
- This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review] PMID: 25230901
- The alternatively spliced variants of the regucalcin gene were found to be expressed in various human normal and tumor tissues. PMID: 25050833
- RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland. PMID: 25128811
- SMP30 can inhibit the proliferation and invasion of human hepatoma cells and thus can be regarded as a cancer suppressive factor. PMID: 24606440
- Overexpression of prostate RGN transgene in the prostate inhibits cell proliferation and apoptotic pathways. PMID: 24975685
- Regucalcin may be a key molecule in lipid metabolic disorder and diabetes--{review} PMID: 23453039
- structural feature of mouse SMP30/GNL seems to facilitate the gamma-lactone-ring formation PMID: 23349732
- Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging PMID: 22652898
- RGN has a role in spermatogenesis, directly or as a mediator of androgen action. [review] PMID: 22121208
- existence of multiple forms of SMP30 PMID: 21347421
- Rgn is a novel androgen-target gene in testis and may have a role in male reproductive function, particularly in the control of spermatogenesis. PMID: 21680783
- Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function. PMID: 21431902
- Data show that regucalcin (RGN) reduces agonist (histamine)-induced Ca(2+) transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca(2+) storage capacity. PMID: 21684279
- SMP30 may be useful for hepatocellular carcinoma serologic screening, especially for the patients that are alpha-fetaprotein negative. PMID: 21047503
- These results suggest that hepatic SMP30 is closely associated with the pathogenesis of nonalcoholic fatty liver disease, although it is not known whether decreased hepatic SMP30 is a result or a cause of cirrhosis PMID: 19946731
- over-expression of SMP30/GNL in Hep G2 cells contributed to a decrease of reactive oxygen species formation accompanied by decreases of lipid peroxidation, superoxide dismutase activity and glutathione levels PMID: 19801822
- a domain of the SMP30 sequence 51 amino acid residues long was 60-66% similar to bacterial and yeast RNA polymerases PMID: 12619687
- SMP30 acts as a survival factor in hepatocytes PMID: 15358188
- crystal structure of regucalcin PMID: 15502314
- SMP30 induces formation of microvilli and bile canaliculi in HepG2 cells. PMID: 15714273
- regucalcin plays an important role as a suppressor in the enhancement of cell proliferation PMID: 15962315
- SMP30 also plays a very important role in a self-protective mechanism in survival and participates in the pathophysiological processes of acute liver failure. PMID: 18507831
- effect of sex steroid hormones on regucalcin expression in breast and prostate cancer cells suggest that it may be associated with development and progression of these human tumors PMID: 19347872
- Data suggest that through regucalcin and L-gulonolactone oxidase expression, beta-catenin regulates vitamin C biosynthesis in liver. PMID: 19690176
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亞細胞定位：Cytoplasm.
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蛋白家族：SMP-30/CGR1 family
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數據庫鏈接：
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