REN Antibody
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中文名稱：REN兔多克隆抗體
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貨號：CSB-PA040200
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Angiotensin forming enzyme antibody; Angiotensin forming enzyme precursor antibody; Angiotensinogenase antibody; Angiotensinogenase precursor antibody; FLJ10761 antibody; HNFJ2 antibody; REN antibody; Ren1 antibody; RENI_HUMAN antibody; Renin antibody; Renin precursor renal antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human Renin.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
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基因功能參考文獻：
- Mean blood pressure, plasma Ang II level, and myocardium malondialdehyde (MDA) content of angiotensinogen-renin (AGT-REN) double transgenic hypertension (dTH) mice were higher than those in wild-type (WT) mice. PMID: 28455747
- This study reveals that the human renin protein is able to complement the mouse Ren1d(-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren1d and human renin proteins. PMID: 29123029
- Findings suggest the prorenin binding to (pro)renin receptor involvement of receptor-associated prorenin system (RAPS) in the pathogenesis of idiopathic epiretinal membrane (iERM). PMID: 28276504
- The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China. PMID: 29233044
- Plasma renin activity is associated with cardiovascular mortality or heart failure readmissions. PMID: 28875746
- In patients with established atherosclerotic disease undergoing carotid endarterectomy, plasma renin and aldosterone concentrations were not associated with atherosclerotic plaque characteristics. Plasma renin concentration was positively associated with the occurrence of major secondary vascular events. PMID: 29548814
- These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development PMID: 27271344
- The genotypes of REN, AT1R and AT2R were not associated with the development of preeclampsia in South African Black women. PMID: 28641212
- Urinary angiotensinogen and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR and these associations are independent of urinary albumin excretion PMID: 28395289
- Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease. PMID: 28747358
- Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio PMID: 28640140
- Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF. PMID: 27927648
- Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA). PMID: 27428770
- Allelic frequency of A of SNP 12109G>A was higher in women with preterm birth than in women with normal vaginal delivery and could be considered a risk factor. PMID: 28019132
- This study demonstrates the efficacy of aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism. PMID: 27534428
- The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese. PMID: 27555048
- Data show that the optimum time for beta-adrenoreceptor antagonists (beta-blockers) withdrawal was 2 weeks when using direct renin concentration (DRC) and 3 weeks for plasma renin activity (PRA). PMID: 26300226
- Active renin was not significantly different between hypertensive patients with and without left ventricular hypertrophy. PMID: 26163660
- The present study provides evidence that the rs1464816 polymorphism in REN is associated with CKD progression in ADPKD. PMID: 26753721
- Plasma renin and Aldosterone to renin ratio but not aldosterone are independently associated with presence of carotid plaques in coronary artery disease patients. PMID: 25237165
- concentrations of serum aldosterone, plasma direct renin, and plasma renin activity were measured after a night's rest and again after walking for two hours. PMID: 25143328
- Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas. PMID: 26489635
- Elevated levels of circulating (pro)renin were observed in pre-eclampsia patients PMID: 25767135
- The results suggest that variants in the enhancer region of the human renin gene have an effect on the expression levels of renin in renal tissue; this observation is in good accordance with the results of the transcriptional assay. PMID: 26366736
- Aliskiren prevents renal disease progression by suppressing both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading. PMID: 24154707
- Primary aldosteronism seems associated with a lower level of prorenin than essential hypertension PMID: 25333683
- Demonstrate that there are strong interactions between prorenin, ATP6AP2, and TGFB1 and that this system has a greater capacity in female amnion to stimulate profibrotic pathways, thus maintaining the integrity of the fetal membranes. PMID: 25491485
- the aldosterone-renin ratio may have role in total and cancer death in Japanese individuals PMID: 25279703
- We conclude that heterozygous substitutions at AGT and REN loci correlate significantly with end-stage renal disease in a north Indian population PMID: 25660845
- Salt supplementation blunts the telmisartan induced increase in plasma renin activity in patients with type 2 diabetes. PMID: 25849646
- our data suggest that the renin polymorphism plays an important role in the risk of developing coronary artery disease with the highest risk for C allele, but do not support its role as a risk factor for developing restenosis after coronary stenting PMID: 26102248
- This study showed no involvement of A/G renin polymorphisms in the pathogenesis of heart failure. PMID: 26076559
- the A allele of rs6682082 of renin is a positive genetic marker for predisposition to essential hypertension and high blood pressure in Korean women. PMID: 25510769
- Data show that administration of bone-marrow-derived stromal cells (BMSCs) with human transgenic angiotensinogen and renin genes in the mouse acute kidney injury (AKI) model resulted in exacerbation of kidney injury. PMID: 25534858
- Urinary renin levels should be measured by established renin assays. PMID: 24742480
- Report ethnic differences in association of plasma renin levels with blood pressure. PMID: 24436325
- We sho a gender-dependent association of the renin rs6693954 SNP with central and ambulatory BP in patients with type 2 diabetes mellitus. PMID: 23358739
- Activation of the renin-angiotensin system in the subfornical organ is sufficient to mediate an increase in drinking through PKC pathway. PMID: 24965793
- Data suggest that the renin-angiotensin system plays a critical role in placentation and nephrogenesis. PMID: 24164175
- These data suggest the importance of the activated oxidative stress/AGT/RAS axis in the pathogenesis of diabetic nephropathy. PMID: 24284398
- renin gene Mbo I site polymorphism is not associated with blood pressure levels and risk of hypertension. PMID: 23108193
- The levels of circulating and local renin-angiotensin-aldosterone system expressions were different in atrial fibrillation patients with different types of mitral valvular diseases. PMID: 23077077
- Plasma renin activity identifies a group of high risk patients for heart failure in patients with chronic kidney disease. PMID: 22459392
- Plasma sPRR concentrations are dependent on ethnicity and independent of renin, prorenin, and aldosterone concentrations in healthy subjects and in patients with contrasted degrees of renin-angiotensin system activity. PMID: 24218434
- the main site of renin in the end-stage kidney is the juxtaglomerular cells. PMID: 23292178
- No significant differences in plasma renin activity are found between patients with polycystic ovary syndrome and controls. PMID: 23461768
- Aldosterone rise that often occurs during prolonged renin-angiotensin system blockade is rather due to the angiotensin II 'escape' during such blockade. PMID: 22396488
- These in vitro data indicate that prorenin acidified in vivo possibly modulate renin angiotensin system in (pro)renin receptor-dependent and/or -independent manners which could ultimately lead to the pathogenesis of diseases. PMID: 23111329
- in twin pregnancies, relative to singleton pregnancies, second trimester plasma level elevated and third trimester level reduced PMID: 22676457
- We observed a disproportionately high level of prorenin in blacks. These high circulating prorenin levels however do not result in greater adrenal angiotensin II and aldosterone production in healthy young blacks. PMID: 22695510
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相關疾病：Renal tubular dysgenesis (RTD); Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)
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亞細胞定位：Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
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蛋白家族：Peptidase A1 family
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