RBP1 Antibody

說明書

中文名稱：

RBP1兔多克隆抗體
貨號：

CSB-PA019480GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RBP1 Polyclonal antibody
Uniprot No.：

P09455
基因名：

RBP1
別名：

Cellular retinol binding protein antibody; Cellular retinol-binding protein antibody; Cellular retinol-binding protein I antibody; CRABP I antibody; CRBP antibody; CRBP-I antibody; CRBP1 antibody; CRBPI antibody; RBP 1 antibody; RBP1 antibody; RBPC antibody; RET1_HUMAN antibody; Retinol binding protein 1 cellular antibody; Retinol-binding protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human RBP1 fusion protein
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.
基因功能參考文獻：
1. Low CRBP1 expression is associated with low radiation sensitivity in rectal cancer. PMID: 28291773
2. This conformational flexibility of human apo-CRBP1 facilitates interaction with the ligands, whereas the more rigid holoprotein structure protects the labile retinoid moiety during vitamin A transport. PMID: 26900151
3. Hypermethylation of CRBP1 gene is associated with Epstein-Barr virus-associated gastric carcinomas. PMID: 25720522
4. Further studies are needed to explore new therapeutic strategies aimed at restoring CRBP-1-mediated intracellular retinol trafficking and the meaning of CRBP-1 expression in cancer patients screening for a more personalized and efficacy retinoid therapy PMID: 25879031
5. RBP1 expression was reduced in tissue and endometrial stromal cells derived from endometritis lesions versus eutopic endometruim in humans and mice. PMID: 25143356
6. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1, that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis. PMID: 23890161
7. Factors involved in the retinoid pathway, in particular upregulation of CRBP, CRABP1 and CRABP2, also showed differential expression in tumors with different histological subtypes PMID: 24269351
8. CRBP-1 loss in G2/G3 ovarian carcinomas and increased apoptotic susceptibility to retinoids. PMID: 24982334
9. Suggest CRBP1 gene as a tumor suppressor gene for cervical cancer. PMID: 24040446
10. High urine retinol binding protein is associated with interstitial fibrosis and tubular atrophy plus inflammation. PMID: 23414180
11. RBP1 promoter hypermethylation is found in nearly all IDH1 and IDH2 mutant gliomas Because RBP1 is involved in retinoic acid synthesis, results suggest that dysregltion of RA metabolism may contribute to glioma formation along the IDH1/IDH2-mutant pathway PMID: 22945948
12. CRBP-1 plays a role in ventricular remodeling after myocardial infarction allegedly through its RA binding activity. PMID: 22449228
13. Increased expression and unmethylated promoter of the CRBP1 gene could be considered as markers for larynx cancer. PMID: 22049223
14. Data show that CRBPI and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal. PMID: 21382444
15. STRA6 not only is a vitamin A transporter but also is a cell-surface signaling receptor activated by the RBP-retinol complex. PMID: 21368206
16. CRBP1 gene could have a tumor suppressive function in bladder cancer. PMID: 21042705
17. It is likely that mutations in RGR, RBP3, and possibly RBP1 occur rarely in inherited retinal dystrophies. PMID: 21067480
18. protein-ligand interaction differences between CRBP-I and CRBP-II PMID: 19965581
19. a high CRBP-1 expression is associated with smooth muscle malignancy and suggest that CRBP-1 expression represents a new useful marker for the classification of unusual variants of smooth muscle tumors PMID: 12111198
20. CRBP1 has a role in vitamin A metabolism and its absence may play a role in ovarian cancer oncogenesis PMID: 12631600
21. may serve as a surrogate marker for graft dysfunction early after kidney transplantation PMID: 12826154
22. in liver cancer modulation of CRBP-1 expression in HCCs contributes to tumor growth and progression via retinoid-mediated signaling and disruption of cellular vitamin A homeostasis. PMID: 12883492
23. Colocalization of plasma retinol-binding protein with RPE65 and affinity binding suggest a direct interaction of RPE65 with plasma retinol-binding protein in cultured human keratinocytes that might be involved in retinoid uptake of keratinocytes. PMID: 15009723
24. in fibrotic or cirrhotic liver, the different patterns of expression for CRBP-1 and alpha-SMA allow the distinction of different subsets of fibroblastic cells involved in fibrogenesis and septa formation PMID: 15094224
25. CRBP-I downregulation in cancer promotes tumor progression through inhibition of retinoic acid receptor activity and derepression of PI3K/Akt signaling via a novel mechanism. PMID: 15608670
26. The widely expressed CRBP1, which binds all-trans-retinol with much higher affinity than all-trans-retinaldehyde, restricts the oxidation of all-trans-retinol by retinol dehydrogenase 12 but has little effect on the reduction of all-trans-retinaldehyde. PMID: 15865448
27. CRBP-1+ cells increased in squamous intraepithelial lesions and slightly decreased in invasive squamous cell carcinomas. PMID: 17593084
28. Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. PMID: 18343808
29. CRBP-1 clearly stains liver lobular HSCs without reacting with smooth muscle cells (SMCs) and shows variable cholangiocyte p PMID: 19052772
30. Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. PMID: 19288010
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亞細胞定位：

Cytoplasm. Lipid droplet.
蛋白家族：

Calycin superfamily, Fatty-acid binding protein (FABP) family
組織特異性：

Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver.
數據庫鏈接：

HGNC: 9919

OMIM: 180260

KEGG: hsa:5947

STRING: 9606.ENSP00000232219

UniGene: Hs.529571

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